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- Table of Contents
PSCA Antibodies
AND PSCA ELISA kits, PSCA Proteins
Many biological assays use antibodies to detect PSCA, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PSCA in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PSCA antibodies...
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PSCA Infographic by Boster Bio
All PSCA Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M02657
100 μg
Cat # M02657
100 μg
PSCA Overview
Facts about Prostate stem cell antigen.
Prostate stem cell antigen (PSCA)
May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro.
.
Gene Information
| Human | |
|---|---|
| Gene Name: | PSCA |
| Uniprot: | O43653 |
| Entrez: | 8000 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
PRO232; prostate stem cell antigen; PSCA
Molecular Weight
Mass (kDA):
11.959 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8q24.3 |
| Sequence: | 8; NC_000008.11 (142670297..142682725) |
Tissue Specificity
Highly expressed in prostate (basal, secretory and neuroendocrine epithelium cells). Also found in bladder (transitional epithelium), placenta (trophoblasts), stomach (neuroendocrine cells), colon (neuroendocrine cells) and kidney (collecting ducts). Overexpressed in prostate cancers and expression is correlated with tumor stage, grade and androgen- independence. Highly expressed in prostate cancer bone metastases. Expressed in gastric epithelial cells, mainly in the isthmus (at protein level). Not detected in normal intestinal epithelium (at protein level). Expressed in brain cortex; expression is significantly increased in the front cortex of Alzheimer disease patients.
Subcellular Localizations
Cell membrane; Lipid-anchor, GPI-anchor.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Prostate
- Prostatic Neoplasms
- Carcinoma
- Neoplasm Metastasis
- Adenocarcinoma
- Malignant Neoplasm Of Stomach
- Carcinogenesis
- Stomach Neoplasms
- Malignant Neoplasm Of Pancreas
- Malignant Paraganglionic Neoplasm
Pathways
- Immune Response
- Cell Growth
- Pathogenesis
- Virulence
- Conjugation
- Localization
- Cell Cycle
- Cell Differentiation
- Methylation
- Reverse Transcription
- Translation
- Oncogenesis
- Cell Proliferation
PTMs
- Methylation
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PSCA
bosterbio.com/bosterbio-gene-info-cards/PSCA
References
PMID: 9465086 by Reiter R.E., et al. Prostate stem cell antigen: a cell surface marker overexpressed in prostate cancer.
PMID: 10973799 by Bahrenberg G., et al. Reduced expression of PSCA, a member of the LY-6 family of cell surface antigens, in bladder, esophagus, and stomach tumors.
2 Publications of Boster PSCA Antibodies & ELISA Kits
- PubMed ID: 27001215, PSCA rs2294008 polymorphism contributes to the decreased risk for cervical cance...
- PubMed ID: 21429770, Zhao Z, Ma W, Zeng G, Qi D, Ou L, Liang Y. Urol Oncol. 2013 Apr;31(3):343-51. Do...
*More publications can be found for each product on its corresponding product page