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- Table of Contents
Presenilin-1 Antibodies
AND PSEN1 ELISA kits, Presenilin-1 Proteins
Many biological assays use antibodies to detect Presenilin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Presenilin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Presenilin-1 antibodies...
Designing a Western blot for Presenilin-1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PSEN1 Western Blot GuidePSEN1 Infographic by Boster Bio
All PSEN1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A00138-3
100 μg/vial
Cat # A00138-3
100 μg/vial
Human, Mouse, Rat
ELISA
$540
Cat # EKC2622
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2622
1 kit, containing two 96-well plates and all necessary reagents
Human
ELISA
$480
Cat # EKC1487
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1487
1 kit, containing one 96-well plate and all necessary reagents
Human
ELISA
$480
Cat # EKC1612
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1612
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A00138S357
100ul
Cat # A00138S357
100ul
PSEN1 Overview
Facts about Presenilin-1.
Presenilin-1 (PSEN1)
Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:15274632, PubMed:10545183, PubMed:10593990, PubMed:10206644, PubMed:10899933, PubMed:10811883, PubMed:12679784, PubMed:12740439, PubMed:25043039, PubMed:26280335). Requires the presence of the other members of the gamma-secretase complex for protease activity (PubMed:15274632, PubMed:25043039, PubMed:26280335).
Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (PubMed:9738936, PubMed:10593990, PubMed:10899933, PubMed:10811883). Stimulates cell-cell adhesion through its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin) (PubMed:11953314).
Gene Information
| Human | |
|---|---|
| Gene Name: | PSEN1 |
| Uniprot: | P49768 |
| Entrez: | 5663 |
Family
| Belongs to: |
|---|
| peptidase A22A family |
Alternative Names
AD3EC 3.4.23.-; Alzheimer disease 3; EC 3.4.23; FAD; presenilin 1; Presenilin1; Presenilin-1; Protein S182; PS-1; PS1presenilin-1; PSEN1; PSNL1; S182
Molecular Weight
Mass (kDA):
52.668 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q24.2 |
| Sequence: | 14; NC_000014.9 (73136436..73223691) |
Tissue Specificity
Detected in azurophile granules in neutrophils and in platelet cytoplasmic granules (at protein level) (PubMed:11987239). Expressed in a wide range of tissues including various regions of the brain, liver, spleen and lymph nodes (PubMed:7596406, PubMed:8641442, PubMed:8574969).
Subcellular Localizations
Endoplasmic reticulum. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic granule. Cell membrane; Multi-pass membrane protein. Cell projection, growth cone. Early endosome. Early endosome membrane; Multi-pass membrane protein. Cell projection, neuron projection. Cell projection, axon. Cell junction, synapse. Translocates with bound NOTCH1 from the endoplasmic reticulum and/or Golgi to the cell surface (PubMed:10593990). Colocalizes with CDH1/2 at sites of cell-cell contact. Colocalizes with CTNNB1 in the endoplasmic r
Diseases
- Alzheimer's Disease
- Alzheimer Disease, Familial
- Dementia
- Plaque, Amyloid
- Neurofibrillary Tangles
- Senile Plaques
- Neurodegenerative Disorders
- Nerve Degeneration
- Dental Plaque
- Neuroblastoma
- Impaired Cognition
- Memory Impairment
- Amyloid Deposition
Interacting Proteins
- APBA1
- Apba2
- APP
- Arc
- BACE1
- CDC37
- ECSIT
- FLOT2
- GAP43
- HCN2
Pathways
- Pathogenesis
- Proteolysis
- Localization
- Cell Death
- Secretion
- Aging
- Transport
- Neurogenesis
- Cognition
- Neuroprotection
- Protein Processing
- Translation
- Cell Adhesion
PTMs
- Cleavage
- Phosphorylation
- Glycosylation
- Methylation
- Gamma-cleavage
- Oxidation
- Biotinylation
Research Areas
- Alzheimers Research
- Apoptosis
- Cancer
- Neuronal Cell Markers
- Neuroscience
- Neurotransmission
- Tumor Suppressors
- Wnt Signaling Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PSEN1
bosterbio.com/bosterbio-gene-info-cards/PSEN1
References
PMID: 7596406 by Sherrington R., et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease.
PMID: 8641442 by Sahara N., et al. Identification and characterization of presenilin I-467, I-463 and I- 374.