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- Table of Contents
Facts about Proteasome subunit beta type-2.
Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required.
Human | |
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Gene Name: | PSMB2 |
Uniprot: | P49721 |
Entrez: | 5690 |
Belongs to: |
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peptidase T1B family |
EC 3.4.25.1; HC7-I; Macropain subunit C7-I; MGC104215; MGC126885; multicatalytic endopeptidase complex subunit C7-1; Multicatalytic endopeptidase complex subunit C7-I; proteasome (prosome, macropain) subunit, beta type, 2; proteasome beta 2 subunit; Proteasome component C7-I; proteasome subunit beta type-2; proteasome subunit, beta type, 2
Mass (kDA):
22.836 kDA
Human | |
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Location: | 1p34.3 |
Sequence: | 1; NC_000001.11 (35599541..35641526, complement) |
Cytoplasm. Nucleus.
PMID: 7918633 by Nothwang H.G., et al. Sequence analyses and inter-species comparisons of three novel human proteasomal subunits, HsN3, HsC7-I and HsC10-II, confine potential proteolytic active-site residues.
PMID: 7811265 by Kristensen P., et al. Human proteasome subunits from 2-dimensional gels identified by partial sequencing.