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PSMD8 Antibodies
AND PSMD8 ELISA kits, PSMD8 Proteins
Many biological assays use antibodies to detect PSMD8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PSMD8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PSMD8 antibodies...
Designing an IHC experiment for PSMD8? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the PSMD8 IHC GuidePSMD8 Infographic by Boster Bio
All PSMD8 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, IF, IHC, ICC, WB
$370
Cat # A12465-1
100 μg/vial
Cat # A12465-1
100 μg/vial
PSMD8 Overview
Facts about 26S proteasome non-ATPase regulatory subunit 8.
26S proteasome non-ATPase regulatory subunit 8 (PSMD8)
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required.
Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. .
Gene Information
| Human | |
|---|---|
| Gene Name: | PSMD8 |
| Uniprot: | P48556 |
| Entrez: | 5714 |
Family
| Belongs to: |
|---|
| proteasome subunit S14 family |
Alternative Names
26S proteasome non-ATPase regulatory subunit 8; 26S proteasome regulatory subunit p31; HIP6,26S proteasome regulatory subunit S14; HYPF; MGC1660; Nin1p; p3126S proteasome regulatory subunit RPN12; proteasome (prosome, macropain) 26S subunit, non-ATPase, 8; Rpn12; S14
Molecular Weight
Mass (kDA):
39.612 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.2 |
| Sequence: | 19; NC_000019.10 (38374550..38383824) |
Diseases
- Malignant Neoplasms
- Stage I Non-small Cell Lung Cancer
- Coronary Heart Disease
- Lung Neoplasms
- Non-neoplastic Disorder
- Non-small Cell Lung Carcinoma
- Malignant Neoplasm Of Breast
- Angina Pectoris
- Atherosclerosis
- Coronary Artery Disease
- Malignant Neoplasm Of Lung
Pathways
- Proteolysis
- Transport
- Fertilization
- Platelet Activation
- Exocytosis
PTMs
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PSMD8
bosterbio.com/bosterbio-gene-info-cards/PSMD8
References
PMID: 7621825 by Kominami K., et al. Nin1p, a regulatory subunit of the 26S proteasome, is necessary for activation of Cdc28p kinase of Saccharomyces cerevisiae.
PMID: 1317798 by Kanayama H.O., et al. Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms.