Prostacyclin synthase Antibodies

AND PTGIS ELISA kits, Prostacyclin synthase Proteins

Many biological assays use antibodies to detect Prostacyclin synthase, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Prostacyclin synthase in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Prostacyclin synthase antibodies...

We validate the specificity of these antibodies to Prostacyclin synthase by testing them on tissues known to express PTGIS positively and negatively. Browse below to find the PTGIS antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PTGIS Infographic by Boster Bio

All PTGIS Products

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Specificity

Applications

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PTGIS (NM_000961) Human Recombinant Protein

Coomassie blue staining of purified PTGIS protein

$1249
Cat # PROTQ16647
20 µg

Anti-PTGIS/PGIS Antibody Picoband®

Western blot analysis of PTGIS/PGIS using anti-PTGIS/PGIS antibody (A05053-2)

Flow Cytometry analysis of U251 cells using anti-PTGIS/PGIS antibody (A05053-2)

Human, Mouse, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A05053-2
100 μg/vial

PTGIS (NM_000961) Human Over-expression Lysate

Human

$628
Cat # LS005740
20 µg, 100 µg

PTGIS Overview

Facts about Prostacyclin synthase.

PTGIS 3D structure. Source: alphafold

Prostacyclin synthase (PTGIS)

Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2). .

Gene Information

Human
Gene Name:	PTGIS
Uniprot:	Q16647
Entrez:	5740

Family

Belongs to:

cytochrome P450 family

Alternative Names

CYP8; CYP8A1; CYP8A1PTGI; CYP8prostacyclin synthase; EC 5.3.99.4; MGC126858; MGC126860; PGIS; PGIScytochrome P450, family 8, subfamily A, polypeptide 1; Prostacyclin Synthase; prostaglandin I2 (prostacyclin) synthase; Prostaglandin I2 synthase; PTGI; PTGIS

Molecular Weight

Mass (kDA):
57.104 kDA

Genomic Context


Human

Location:	20q13.13
Sequence:	20; NC_000020.11 (49503874..49568137, complement)

Tissue Specificity

Widely expressed; particularly abundant in ovary, heart, skeletal muscle, lung and prostate.

Subcellular Localizations

Endoplasmic reticulum membrane; Single-pass membrane protein.

Diseases

Malignant Neoplasms
Hypertensive Disease
Infarction
Cholangiocarcinoma
Neoplasms
Myocardial Infarction
Malignant Neoplasm Of Breast
Mammary Neoplasms
Colorectal Neoplasms
Colorectal Cancer
Neoplasm Metastasis
Metastatic Malignant Neoplasm To The Liver
Malignant Tumor Of Colon

Pathologic Vasoconstriction
Liver Neoplasms
Endometrial Polyp
Cardiovascular Diseases
Cerebrovascular Accident
Ischemic Stroke
Atherosclerosis

Pathways

Methylation
Decidualization
Translational Initiation
Translational Termination
Dna Methylation
Cell Growth
Vasoconstriction
Fatty Acid Oxidation
Pathogenesis

Myoblast Differentiation
Localization
Platelet Aggregation

PTMs

Methylation

Demethylation

Oxidation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PTGIS

References

PMID: 8185632 by Miyata A., et al. Molecular cloning and expression of human prostacyclin synthase.

PMID: 11281454 by Chevalier D., et al. Characterization of new mutations in the coding sequence and 5'- untranslated region of the human prostacyclin synthase gene (CYP8A1).