Poliovirus receptor (PVR)

Mediates NK cell adhesion and triggers NK cell effector functions. Binds two distinct NK cell receptors: CD96 and CD226.

These interactions accumulates at the cell-cell contact site, leading to the creation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and trigger cytoxicity of activated NK cells.