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- Table of Contents
Facts about Protein kinase C and casein kinase substrate in neurons protein 2.
Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. May also play a role in the formation of caveolae at the cell membrane.
| Human | |
|---|---|
| Gene Name: | PACSIN2 |
| Uniprot: | Q9UNF0 |
| Entrez: | 11252 |

| Belongs to: |
|---|
| PACSIN family |

cytoplasmic phosphoprotein PACSIN2; protein kinase C and casein kinase substrate in neurons 2; protein kinase C and casein kinase substrate in neurons protein 2; SDPII; syndapin II
Mass (kDA):
55.739 kDA

| Human | |
|---|---|
| Location: | 22q13.2 |
| Sequence: | 22; NC_000022.11 (42869766..43015176, complement) |
Widely expressed.
Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Recycling endosome membrane. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Membrane, caveola. Detected at the neck of flask-shaped caveolae. Localization to tubular recycling endosomes probably requires interaction with MICALL1 and EHD1.





PMID: 10431838 by Ritter B., et al. PACSIN 2, a novel member of the PACSIN family of cytoplasmic adapter proteins.
PMID: 11082044 by Modregger J., et al. All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis.