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- Table of Contents
RAB27A Antibodies
AND RAB27A ELISA kits, RAB27A Proteins
Many biological assays use antibodies to detect RAB27A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RAB27A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RAB27A antibodies...
Designing a Western blot for RAB27A? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the RAB27A Western Blot GuideDesigning an IHC experiment for RAB27A? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the RAB27A IHC GuideRAB27A Infographic by Boster Bio
All RAB27A Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M01608
100 μg/vial
Cat # M01608
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, ICC, WB
$370
Cat # A01608-1
100 μg/vial
Cat # A01608-1
100 μg/vial
Human
Flow Cytometry, IP, IF, ICC, WB
$370
Cat # M01608-2
100 μl/vial
Cat # M01608-2
100 μl/vial
RAB27A Overview
Facts about Ras-related protein Rab-27A.
Ras-related protein Rab-27A (RAB27A)
Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming in the immunologic synapse.
.
Gene Information
| Human | |
|---|---|
| Gene Name: | RAB27A |
| Uniprot: | P51159 |
| Entrez: | 5873 |
Family
| Belongs to: |
|---|
| small GTPase superfamily |
Alternative Names
GS2; GS2rab-27; GTP-binding protein Ram; HsT18676; Rab-27; Rab27a; RAB27A, member RAS oncogene family; RAB27MGC117246; RAM; RAMras-related protein Rab-27A
Molecular Weight
Mass (kDA):
24.868 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 15q21.3 |
| Sequence: | 15; NC_000015.10 (55202966..55291338, complement) |
Tissue Specificity
Found in all the examined tissues except in brain. Low expression was found in thymus, kidney, muscle and placenta. Detected in melanocytes, and in most tumor cell lines examined. Expressed in cytotoxic T-lymphocytes (CTL) and mast cells.
Subcellular Localizations
Membrane; Lipid-anchor. Melanosome. Late endosome. Lysosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545, PubMed:17081065). Localizes to endosomal exocytic vesicles (PubMed:17237785).
Diseases
- Hypopigmentation-immunodeficiency Disease
- Immunologic Deficiency Syndromes
- Lymphohistiocytosis, Hemophagocytic
- Albinism
- Piebaldism
- Neoplasms
- Griscelli Syndrome, Type 2
- Melanoma
- Hypopigmentation Disorder
- Malignant Neoplasms
- Infective Disorder
- Hermanski-pudlak Syndrome
Interacting Proteins
- MLPH
Pathways
- Exocytosis
- Transport
- Secretion
- Melanosome Transport
- Localization
- Pigmentation
- Insulin Secretion
- Secretory Pathway
- Vesicle Transport
- Endocytosis
- Pathogenesis
- Rna Interference
- Prenylation
PTMs
- Prenylation
- Phosphorylation
- Geranylgeranylation
- Glycosylation
- Biotinylation
Research Areas
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RAB27A
bosterbio.com/bosterbio-gene-info-cards/RAB27A
References
PMID: 7592656 by Seabra M.C., et al. Deficient geranylgeranylation of Ram/Rab27 in choroideremia.
PMID: 9066979 by Chen D., et al. Molecular cloning and characterization of rab27a and rab27b, novel human rab proteins shared by melanocytes and platelets.