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- Table of Contents
RAP1B Antibodies
AND RAP1B ELISA kits, RAP1B Proteins
Many biological assays use antibodies to detect RAP1B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RAP1B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RAP1B antibodies...
Designing a Western blot for RAP1B? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the RAP1B Western Blot GuideRAP1B Infographic by Boster Bio
All RAP1B Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IP, WB
$370
Cat # M01848
100 μl/vial
Cat # M01848
100 μl/vial
Human, Mouse, Rat
ELISA
$540
Cat # EKC2204
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2204
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC1952
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC1952
1 kit, containing two 96-well plates and all necessary reagents
RAP1B Overview
Facts about Ras-related protein Rap-1b.
Ras-related protein Rap-1b (RAP1B)
GTP-binding protein which possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen.
Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 into the cell junction. Plays a role in the establishment of basal endothelial barrier function.
Gene Information
| Human | |
|---|---|
| Gene Name: | RAP1B |
| Uniprot: | P61224 |
| Entrez: | 5908 |
Family
| Belongs to: |
|---|
| small GTPase superfamily |
Alternative Names
DKFZp586H0723; GTP-binding protein smg p21B; KREV; K-REV; RAL1B; Rap1B; RAP1B, member of RAS oncogene family; Ras family small GTP binding protein RAP1B; RAS-related protein RAP1B; ras-related protein Rap-1b; small GTP binding protein
Molecular Weight
Mass (kDA):
20.825 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q15 |
| Sequence: | 12; NC_000012.12 (68610899..68671901) |
Subcellular Localizations
Cell membrane. Cytoplasm, cytosol. Cell junction. May shuttle between plasma membrane and cytosol. Presence of KRIT1 and CDH5 is required for its localization to the cell junction.
Diseases
- Tissue Adhesions
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Thrombus
- Thrombosis
- Cell Transformation, Neoplastic
- Diabetic Nephropathy
- Hemorrhage
- Kidney Diseases
- Tumor Angiogenesis
- Malignant Paraganglionic Neoplasm
- Glioma
Interacting Proteins
- RALGDS
- RAP1GAP
- RASSF5
Pathways
- Platelet Aggregation
- Platelet Activation
- Localization
- Cell Proliferation
- Cell Adhesion
- Secretion
- Integrin Activation
- Chemotaxis
- Cell Activation
- Cell Cycle
- Cell Growth
- Angiogenesis
- Cell Migration
PTMs
- Phosphorylation
- Farnesylation
- Prenylation
- Cleavage
- Geranylgeranylation
Research Areas
- Endosome Markers
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RAP1B
bosterbio.com/bosterbio-gene-info-cards/RAP1B
References
PMID: 3137530 by Pizon V., et al. Nucleotide sequence of a human cDNA encoding a ras-related protein (rap1B).
PMID: 3141412 by Bokoch G.M., et al. Purification and characterization of the 22,000-dalton GTP-binding protein substrate for ADP-ribosylation by botulinum toxin, G22K.