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- Table of Contents
Facts about REST corepressor 1.
In the BHC complicated, it serves as a molecular beacon for the recruitment of molecular machinery, such as MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates.
Human | |
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Gene Name: | RCOR1 |
Uniprot: | Q9UKL0 |
Entrez: | 23186 |
Belongs to: |
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CoREST family |
CoREST; KIAA0071CORESTRCORREST corepressor; Protein CoREST; RCOR1; RCOR1/CoREST; REST corepressor 1
Mass (kDA):
53.327 kDA
Human | |
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Location: | 14q32.31-q32.32 |
Sequence: | 14; NC_000014.9 (102592593..102730572) |
Ubiquitously expressed.
Nucleus. Upon infection by HSV-1, it is partially translocated into the cytoplasm in an HSV-1-dependent manner.
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The RCOR1 marker is an important biomarker for transcriptional regulation. It acts as a general repressor of gene expression over short time scales. Therefore, modifying RCOR1 levels will affect transcription globally. This marker has several applications, including transcriptional regulation. Listed below are some of the best uses of this marker. Read on to discover more. This article explores several uses of the RCOR1 gene marker.
RNA-seq analysis was performed using two datasets. Using two different antibodies, these datasets were compared. The heatmaps of the signals represent gene occupancies relative to the intensity of the RNA-seq data. In both datasets, RCOR1 clusters I and II were found. RCOR1 is found to be present in two distinct cellular compartments, clustered in groups.
RCOR1 functions in the cell's nucleoplasmic membrane and is involved in the regulation of gene expression. This protein is a member of the LSD1-RCOR1-HDAC1/2 complex, which represses transcription by erasing histone modifications. RCOR1 stimulates the activity of these enzymes in nucleosomal membranes.
RCOR1-related soluble nuclear species are more readily extracted from nucleic acid than classical heterochromatin markers. The presence of RCOR1-related soluble nuclear species may reflect the presence of RCOR1 at different chromatin and nucleoplasmic compartments, thereby facilitating cell characterization in multiple settings. It is possible that the RCOR1 complex has a higher extractability compared to the classical heterochromatin markers.
In experiments with the RCOR1 marker, a control group is used to assess whether the gene is being overexpressed. Using the Corin molecule, RCOR1 protein levels are significantly lowered in HT22 cells. RCOR1 immunoprecipitation shows co-immunoprecipitated RPB1 transcripts and the post-translational modifications of RPB1.
The RCOR1 gene encodes the tRNA RNA polymerase (tRNAp) and is essential for the regulation of several key cellular processes. The gene is expressed in many different tissues, including the brain, heart, and kidney, and is also found in a wide range of cancers. Researchers are now able to use this gene to detect the presence of various cancer-related molecules and to identify the cancer that caused them.
PMID: 10449787 by Andres M.E., et al. CoREST: a functional corepressor required for regulation of neural- specific gene expression.
PMID: 10734093 by Grimes J.A., et al. The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex.