This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about REST corepressor 1.
In the BHC complicated, it serves as a molecular beacon for the recruitment of molecular machinery, such as MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates.
Human | |
---|---|
Gene Name: | RCOR1 |
Uniprot: | Q9UKL0 |
Entrez: | 23186 |
Belongs to: |
---|
CoREST family |
CoREST; KIAA0071CORESTRCORREST corepressor; Protein CoREST; RCOR1; RCOR1/CoREST; REST corepressor 1
Mass (kDA):
53.327 kDA
Human | |
---|---|
Location: | 14q32.31-q32.32 |
Sequence: | 14; NC_000014.9 (102592593..102730572) |
Ubiquitously expressed.
Nucleus. Upon infection by HSV-1, it is partially translocated into the cytoplasm in an HSV-1-dependent manner.
PMID: 10449787 by Andres M.E., et al. CoREST: a functional corepressor required for regulation of neural- specific gene expression.
PMID: 10734093 by Grimes J.A., et al. The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex.