Transcription factor RelB (RELB)

NF-kappa-B is a pleiotropic transcription factor that's present in virtually all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell development, tumorigenesis and apoptosis. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B websites that they can bind with distinguishable affinity and specificity.

Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization in addition to by interactions with other cofactors or corepressors.