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RGS2 Antibodies
AND RGS2 ELISA kits, RGS2 Proteins
Many biological assays use antibodies to detect RGS2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RGS2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RGS2 antibodies...
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RGS2 Infographic by Boster Bio
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RGS2 Overview
Facts about Regulator of G-protein signaling 2.
Regulator of G-protein signaling 2 (RGS2)
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11063746, PubMed:19478087).
It is involved in the negative regulation of this angiotensin-activated signaling pathway (PubMed:28784619). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ.
Gene Information
| Human | |
|---|---|
| Gene Name: | RGS2 |
| Uniprot: | P41220 |
| Entrez: | 5997 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
Cell growth-inhibiting gene 31 protein; G0 to G1 switch regulatory 8, 24kD; G0/G1 switch regulatory protein 8; G0S8cell growth-inhibiting protein 31; regulator of G-protein signaling 2; regulator of G-protein signaling 2, 24kDa; regulator of G-protein signalling 2, 24kD; regulator of G-protein signalling 2, 24kDa
Molecular Weight
Mass (kDA):
24.382 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q31.2 |
| Sequence: | 1; NC_000001.11 (192809039..192812275) |
Tissue Specificity
Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL).
Subcellular Localizations
[Isoform 1]: Cell membrane. Cytoplasm. Nucleus, nucleolus.; [Isoform 2]: Cell membrane. Cytoplasm. Nucleus, nucleolus.; [Isoform 3]: Cell membrane. Cytoplasm. Nucleus, nucleolus.; [Isoform 4]: Cell membrane. Mitochondrion.
Diseases
- Hypertensive Disease
- Pertussis
- Hypertrophy
- Malignant Neoplasms
- Anxiety Disorders
- Heart Failure
- Neoplasms
- Nervousness
- Cardiovascular Diseases
- Pathologic Vasoconstriction
- Schizophrenia
- Cardiac Hypertrophy
- Panic Disorder
Interacting Proteins
- Gnaq
- LRRK2
- MTUS2
- PPP1R9A
Pathways
- Localization
- Secretion
- Pathogenesis
- Transport
- Cell Growth
- Cell Migration
- Cell Proliferation
- Translation
- Cell Cycle
- Cell Differentiation
- Rna Interference
- Excretion
- Chemotaxis
PTMs
- Phosphorylation
- Dephosphorylation
- Cleavage
- Sumoylation
- Nitrosylation
- Prenylation
Research Areas
- Cell Cycle and Replication
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RGS2
bosterbio.com/bosterbio-gene-info-cards/RGS2
References
PMID: 8179820 by Siderovski D.P., et al. A human gene encoding a putative basic helix-loop-helix phosphoprotein whose mRNA increases rapidly in cycloheximide-treated blood mononuclear cells.
PMID: 11278586 by Heximer S.P., et al. Mechanisms governing subcellular localization and function of human RGS2.