E3 ubiquitin-protein ligase RLIM (Rlim)

E3 ubiquitin-protein ligase that serves as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners like RLIM.

Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, functions as an activator of random inactivation of X chromosome from the embryo, a stochastic process where X chromosome is inactivated to minimize sex- related dose differences of X-encoded genes in somatic cells of female placental mammals.