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- Table of Contents
ROR1 Antibodies
AND ROR1 ELISA kits, ROR1 Proteins
Many biological assays use antibodies to detect ROR1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ROR1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ROR1 antibodies...
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ROR1 Infographic by Boster Bio
All ROR1 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M03192-1
100 μg
Cat # M03192-1
100 μg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M03192-2
100 μg
Cat # M03192-2
100 μg
ROR1 Overview
Facts about Inactive tyrosine-protein kinase transmembrane receptor ROR1.
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Has very low kinase activity in vitro and is unlikely to be a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which trigger downstream NFkB signaling pathway and might result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350).
In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350). .
Gene Information
| Human | |
|---|---|
| Gene Name: | ROR1 |
| Uniprot: | Q01973 |
| Entrez: | 4919 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.10.1; MGC99659; neurotrophic tyrosine kinase receptor-related 1; Neurotrophic tyrosine kinase, receptor-related 1; NTRKR1; NTRKR1dJ537F10.1; receptor tyrosine kinase-like orphan receptor 1; ROR1; tyrosine-protein kinase transmembrane receptor ROR1
Molecular Weight
Mass (kDA):
104.283 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p31.3 |
| Sequence: | 1; NC_000001.11 (63774017..64181498) |
Tissue Specificity
Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm.
Subcellular Localizations
Membrane; Single-pass type I membrane protein. Cell projection, axon.
Diseases
- Malignant Neoplasms
- Leukemia
- Lymphoid Leukemia
- Chronic Lymphocytic Leukemia
- Neoplasms
- Nervousness
- Acute Lymphocytic Leukemia
- Lymphoma
- Malignant Neoplasm Of Stomach
- Cell Invasion
- Malignant Neoplasm Of Breast
- Plant Diseases
- Malignant Paraganglionic Neoplasm
Interacting Proteins
- EGFR
- SRC
- Src
Pathways
- Localization
- Gene Silencing
- Methylation
- Cell Migration
- Dna Methylation
- Glycosylation
- Cell Death
- Secretion
- Cell Adhesion
- Cell Division
- Convergent Extension
- Dna Repair
- Complement-dependent Cytotoxicity
PTMs
- Phosphorylation
- Methylation
- Glycosylation
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ROR1
bosterbio.com/bosterbio-gene-info-cards/ROR1
References
PMID: 1334494 by Masiakowski P., et al. A novel family of cell surface receptors with tyrosine kinase-like domain.
PMID: 8875995 by Reddy U.R., et al. Human neural tissues express a truncated Ror1 receptor tyrosine kinase, lacking both extracellular and transmembrane domains.