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- Table of Contents
Facts about GTP-binding protein RAD.
Inhibits cardiac hypertrophy during the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D.
Human | |
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Gene Name: | RRAD |
Uniprot: | P55042 |
Entrez: | 6236 |
Belongs to: |
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small GTPase superfamily |
RAD1; RADGTP-binding protein RAD; RAS (RAD and GEM) like GTP binding 3; Ras associated with diabetes; Ras-related associated with diabetes; REM3
Mass (kDA):
33.245 kDA
Human | |
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Location: | 16q22.1 |
Sequence: | 16; NC_000016.10 (66921679..66925536, complement) |
Most abundantly expressed in the heart. Also found in the skeletal muscle and lung. Lesser amounts in placenta and kidney. Also detected in adipose tissue. Overexpressed in muscle of type II diabetic humans.
Cell membrane.
PMID: 8248782 by Reynet C., et al. Rad: a member of the Ras family overexpressed in muscle of type II diabetic humans.
PMID: 9115241 by Moyers J.S., et al. Rad and Rad-related GTPases interact with calmodulin and calmodulin- dependent protein kinase II.