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- Table of Contents
Facts about Reticulon-1.
Human | |
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Gene Name: | RTN1 |
Uniprot: | Q16799 |
Entrez: | 6252 |
Belongs to: |
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No superfamily |
NSP-A; RTN1; RTN1A; RTN1-A
Mass (kDA):
83.618 kDA
Human | |
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Location: | 14q23.1 |
Sequence: | 14; NC_000014.9 (59595976..59871288, complement) |
Expressed in neural and neuroendocrine tissues and cell cultures derived therefrom. Expression of isoform RTN1-C is strongly correlated with neuronal differentiation.
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
If you are looking for the best antibody to use for the RTN1 Marker, you have come to the right place. We have compiled information on Steven Boster's background, primary antibodies, and career to make it easier to choose the best one for your needs. Continue reading to find out more about Steven Boster. This article will focus on his most important discoveries as well as his career as an investigator.
His primary antibodies can be used for studying many biological systems. They can detect RTN1 protein in a variety cell types and tissues. There are many formats available for the antibodies, including mouse monoclonal antibodies and goat anti-rabbit IgG as well as rabbit anti-mouse IgG. Monoclonal mouse antibodies are the most commonly used format.
The RTN1 antibody recognizes a particular protein found in the ER. RTN1 proteins are classified according the C-terminal domains. These proteins are responsible for controlling tubular endoplasmicreticulum network. RTN1 is a membrane protein that functions in promoting membrane curvature. RTN1 can be found in three forms. The ER–localization signal isn't conserved among the different isoforms.
His research on RTN1 indicates that this protein may be a marker for neuroendocrine tumours. This protein inhibits the anti-apoptotic activities of BCL2L1, which encodes BCL2-like 1 protein or BCL2-XL. This mutation alters BclxL protein's subcellular location and disrupts its anti-apoptotic activities.
Since its discovery in 2003 the RTN1 genes has been considered to be a marker for neuroendocrine tumours. It alters the subcellular distribution BCL2L1 ("Bcl2-like 1/1/Bcl2-extra large proteins"), thereby disrupting its anti-apoptotic activities. Although there are many other possible uses for the RTN1 genes in cancer research it is most well-known for its role in the development of neuroendocrine tumours.
PMID: 7685762 by Roebroek A.J.M., et al. Cloning and expression of alternative transcripts of a novel neuroendocrine-specific gene and identification of its 135-kDa translational product.
PMID: 8833145 by Roebroek A.J.M., et al. Genomic organization of the human NSP gene, prototype of a novel gene family encoding reticulons.