Sacsin Antibodies

AND SACS ELISA kits, Sacsin Proteins

Many biological assays use antibodies to detect Sacsin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Sacsin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Sacsin antibodies...

We validate the specificity of these antibodies to Sacsin by testing them on tissues known to express SACS positively and negatively. Browse below to find the SACS antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SACS Infographic by Boster Bio

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Anti-Sacsin Antibody

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IHC analysis of SACS using anti-SACS antibody (A00519)

IHC analysis of Sacsin using anti-Sacsin antibody (A00519)

Human, Mouse, Rat

ELISA, IHC

$370
Cat # A00519
100 μg/vial

SACS Overview

Facts about Sacsin.

Sacsin (SACS)

Co-chaperone which functions as a regulator of the Hsp70 chaperone machines and might be involved in the processing of other ataxia-linked proteins. .

Gene Information

Human
Gene Name:	SACS
Uniprot:	Q9NZJ4
Entrez:	26278

Family

Belongs to:

No superfamily

Alternative Names

ARSACS; dnaJ homolog subfamily C member 29; DNAJC29; KIAA0730; SACS; Sacsin; spastic ataxia of Charlevoix-Saguenay (sacsin)

Molecular Weight

Mass (kDA):
521.126 kDA

Genomic Context


Human

Location:	13q12.12
Sequence:	13; NC_000013.11 (23328827..23433728, complement)

Tissue Specificity

Highly expressed in the central nervous system. Also found in skeletal muscle and at low levels in pancreas.

Subcellular Localizations

Cytoplasm. Predominantly cytoplasmic, a small portion is present in the nucleus and also shows a partial mitochondrial overlap with the mitochondrial marker Hsp60.

Diseases

Ataxia
Spastic Ataxia, Charlevoix-saguenay Type
Muscle Spasticity
Cerebellar Ataxia
Ataxia, Spinocerebellar
Neurodegenerative Disorders
Atrophy
Hypokinesia
Peripheral Neuropathy
Hernia
Hernia, Inguinal
Spinocerebellar Degeneration

Cytogenetic Abnormality
Early Onset Cerebellar Ataxia
Infarction
Myocardial Infarction
Nerve Degeneration
Nervousness

Pathways

Transport
Excretion
Pathogenesis
Cell Death
Programmed Cell Death
Intestinal Absorption
Cholesterol Transport
Cognition
Localization
Protein Folding
Hibernation
Muscle Cell Differentiation
Chaperone-mediated Protein Folding

Intracellular Cholesterol Transport
Oxidative Phosphorylation
Spermatogenesis
Swimming
Mitochondrial Transport
System Development
Cholesterol Efflux

PTMs

Phosphorylation
Oxidation

Dephosphorylation
Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SACS

References

PMID: 10655055 by Engert J.C., et al. ARSACS, a spastic ataxia common in northeastern Quebec, is caused by mutations in a new gene encoding an 11.5-kb ORF.

PMID: 19208651 by Parfitt D.A., et al. The ataxia protein sacsin is a functional co-chaperone that protects against polyglutamine-expanded ataxin-1.