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DNA-binding protein SATB1 Antibodies
AND SATB1 ELISA kits, DNA-binding protein SATB1 Proteins
Many biological assays use antibodies to detect DNA-binding protein SATB1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DNA-binding protein SATB1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DNA-binding protein SATB1 antibodies...
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SATB1 Infographic by Boster Bio
All SATB1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M01312
100 μl
Cat # M01312
100 μl
Anti-SATB1 Antibody Picoband®
1 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, ICC, WB
$370
Cat # A01312-1
100 μg/vial
Cat # A01312-1
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, WB
$523
Cat # M01312-1
100 µl
Cat # M01312-1
100 µl
SATB1 Overview
Facts about DNA-binding protein SATB1.
DNA-binding protein SATB1 (SATB1)
Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to comprehend the sugar-phosphate arrangement of double-stranded DNA.
Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for many chromatin remodeling enzymes (e.
Gene Information
| Human | |
|---|---|
| Gene Name: | SATB1 |
| Uniprot: | Q01826 |
| Entrez: | 6304 |
Family
| Belongs to: |
|---|
| CUT homeobox family |
Alternative Names
DNA-binding protein SATB1; SATB homeobox 1; SATB1; special AT-rich sequence binding protein 1 (binds to nuclearmatrix/scaffold-associating DNA's); Special AT-rich sequence-binding protein 1
Molecular Weight
Mass (kDA):
85.957 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3p24.3 |
| Sequence: | 3; NC_000003.12 (18345377..18445592, complement) |
Tissue Specificity
Expressed predominantly in thymus.
Subcellular Localizations
Nucleus matrix. Nucleus, PML body. Organized into a cage-like network anchoring loops of heterochromatin and tethering specialized DNA sequences. When sumoylated, localized in promyelocytic leukemia nuclear bodies (PML NBs).
Diseases
- Malignant Neoplasms
- Neoplasms
- Neoplasm Metastasis
- Mammary Neoplasms
- Carcinoma
- Malignant Neoplasm Of Breast
- Malignant Paraganglionic Neoplasm
- Lymphoma
- Metastatic Malignant Neoplasm To The Lymph Node
- Acute Erythroblastic Leukemia
- Lymphatic Metastasis
- Carcinogenesis
Interacting Proteins
- CASP6
- CTNNB1
- SUMO1
- SUMO1P1
Pathways
- Chromatin Remodeling
- Cell Differentiation
- Chromatin Organization
- Localization
- Pathogenesis
- Cell Cycle
- Cell Development
- Methylation
- Histone Acetylation
- Cell Proliferation
- Cell Death
- Dna Replication
- Proteolysis
PTMs
- Acetylation
- Methylation
- Cleavage
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SATB1
bosterbio.com/bosterbio-gene-info-cards/SATB1
References
PMID: 1505028 by Dickinson L.A., et al. A tissue-specific MAR/SAR DNA-binding protein with unusual binding site recognition.
PMID: 9111059 by Dickinson L.A., et al. An atypical homeodomain in SATB1 promotes specific recognition of the key structural element in a matrix attachment region.