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SEC61A1 Antibodies
AND SEC61A1 ELISA kits, SEC61A1 Proteins
Many biological assays use antibodies to detect SEC61A1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SEC61A1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SEC61A1 antibodies...
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SEC61A1 Overview
Facts about Protein transport protein Sec61 subunit alpha isoform 1.
Protein transport protein Sec61 subunit alpha isoform 1 (SEC61A1)
Part of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore at the ER membrane, both works required for cotranslational translocation of nascent polypeptides (PubMed:22375059, PubMed:28782633, PubMed:29719251).
May collaborate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to allow post- translational transport of small presecretory proteins (PubMed:22375059, PubMed:29719251). Controls the passive efflux of calcium ions from the ER lumen to the cytosol via SEC61 channel, leading to the maintenance of cellular calcium homeostasis (PubMed:28782633).
Gene Information
| Human | |
|---|---|
| Gene Name: | SEC61A1 |
| Uniprot: | P61619 |
| Entrez: | 29927 |
Family
| Belongs to: |
|---|
| SecY/SEC61-alpha family |
Alternative Names
HSEC61; protein transport protein SEC61 alpha subunit; protein transport protein Sec61 subunit alpha isoform 1; protein transport protein Sec61 subunit alpha; Sec61 alpha 1 subunit (S. cerevisiae); Sec61 alpha-1; sec61 homolog; SEC61; SEC61A
Molecular Weight
Mass (kDA):
52.265 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3q21.3 |
| Sequence: | 3; NC_000003.12 (128052437..128071683) |
Tissue Specificity
Expressed in proximal and distal tubules in kidney (at protein level).
Subcellular Localizations
Endoplasmic reticulum membrane; Multi-pass membrane protein. Localizes exclusively in granular structures in the endoplasmic reticulum (ER).
Diseases
- Diabetes Mellitus
- Diabetes Mellitus, Non-insulin-dependent
- Liver Carcinoma
- Liver Diseases
- Nerve Degeneration
- Endoplasmic Reticulum Stress
- Prostatic Neoplasms
- Polycystic Liver Disease
- Malignant Neoplasms
- Cytomegalovirus Infections
Interacting Proteins
- CANX
- HSPA5
Pathways
- Transport
- Protein Transport
- Response To Stress
- Translation
- Gene Silencing
- Cell Growth
- Pathogenesis
- Response To Endoplasmic Reticulum Stress
PTMs
- Phosphorylation
Research Areas
- Membrane Trafficking and Chaperones
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SEC61A1
bosterbio.com/bosterbio-gene-info-cards/SEC61A1
References
PMID: 22375059 by Lang S., et al. Different effects of Sec61alpha, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells.
PMID: 29719251 by Hassdenteufel S., et al. Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier.