Neuroserpin Antibodies

AND SERPINI1 ELISA kits, Neuroserpin Proteins

Many biological assays use antibodies to detect Neuroserpin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Neuroserpin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Neuroserpin antibodies...

We validate the specificity of these antibodies to Neuroserpin by testing them on tissues known to express SERPINI1 positively and negatively. Browse below to find the SERPINI1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SERPINI1 Infographic by Boster Bio

All SERPINI1 Products

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Anti-Neuroserpin/SERPINI1 Antibody Picoband®

1 Q&As

Western blot analysis of Neuroserpin using anti-Neuroserpin antibody (PB9744)

Human, Mouse, Rat

$370
Cat # PB9744
100 μg/vial

Anti-Neuroserpin (SERPINI1) Mouse Monoclonal Antibody [Clone ID: OTI1A5]

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SERPINI1 (Right lane) cDNA for 48 hrs and lysed

Human, Mouse, Rat

$523
Cat # M08266
100 µl

SERPINI1 Overview

Facts about Neuroserpin.

SERPINI1 3D structure. Source: alphafold

Neuroserpin (SERPINI1)

Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin (PubMed:9442076, PubMed:26329378, PubMed:19265707, PubMed:19285087, PubMed:11880376). May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the mature nervous system.

May protect neurons from cell damage by tissue-type plasminogen activator (Probable). .

Gene Information

Human
Gene Name:	SERPINI1
Uniprot:	Q99574
Entrez:	5274

Family

Belongs to:

serpin family

Alternative Names

DKFZp781N13156; Neuroserpin; Peptidase inhibitor 12; PI12; PI-12; PI12Serpin I1; serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1; Serpin I1; serpin peptidase inhibitor, clade I (neuroserpin), member 1

Molecular Weight

Mass (kDA):
46.427 kDA

Genomic Context


Human

Location:	3q26.1
Sequence:	3; NC_000003.12 (167735721..167825569)

Tissue Specificity

Detected in brain cortex and hippocampus pyramidal neurons (at protein level) (PubMed:17040209). Predominantly expressed in the brain (PubMed:9070919).

Subcellular Localizations

Secreted. Cytoplasmic vesicle, secretory vesicle lumen. Perikaryon.

Diseases

Neoplasms
Malignant Neoplasms
Brain Neoplasms
Dementia
Carcinoma
Glioblastoma
Brain Diseases
Stomach Neoplasms
Encephalopathy, Familial, With Neuroserpin Inclusion Bodies
Teratoma
Neurodegenerative Disorders
Malignant Neoplasm Of Brain
Glioma

Carcinogenesis
Parkinson Disease
Cavernous Hemangioma Of Brain
Cerebrovascular Accident
Dementias, Familial
Nervousness
Medulloblastoma

Pathways

Methylation
Dna Replication
Programmed Cell Death
Cell Death
Cell Cycle
Brain Development
Neurogenesis

Pathogenesis

PTMs

Glycoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SERPINI1

References

PMID: 9070919 by Schrimpf S.P., et al. Human neuroserpin (PI12): cDNA cloning and chromosomal localization to 3q26.

PMID: 9442076 by Osterwalder T., et al. The axonally secreted serine proteinase inhibitor, neuroserpin, inhibits plasminogen activators and plasmin but not thrombin.