This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
SETMAR Antibodies
AND SETMAR ELISA kits, SETMAR Proteins
Many biological assays use antibodies to detect SETMAR, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SETMAR in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SETMAR antibodies...
Previous: CBLIF
Next: SFPQ
SETMAR Infographic by Boster Bio
All SETMAR Products
Product
Figures
Specificity
Applications
Price
SETMAR Overview
Facts about Histone-lysine N-methyltransferase SETMAR.
Histone-lysine N-methyltransferase SETMAR (SETMAR)
Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double-strand break repair, stalled replication fork restart and DNA integration. DNA-binding protein, it is indirectly recruited to sites of DNA damage through protein-protein interactions.
Has also kept a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity (PubMed:16332963, PubMed:16672366, PubMed:17877369, PubMed:17403897, PubMed:18263876, PubMed:22231448, PubMed:24573677, PubMed:20521842). In parallel, has a histone methyltransferase activity and methylates 'Lys-4' and 'Lys-36' of histone H3.
Gene Information
| Human | |
|---|---|
| Gene Name: | SETMAR |
| Uniprot: | Q53H47 |
| Entrez: | 6419 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
EC 2.1.1.43; histone-lysine N-methyltransferase SETMAR; hsMar1; METNASE; SET domain and mariner transposase fusion gene; SET domain and mariner transposase fusion gene-containing protein
Molecular Weight
Mass (kDA):
78.034 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3p26.1 |
| Sequence: | 3; NC_000003.12 (4303304..4320649) |
Tissue Specificity
Widely expressed, with highest expression in placenta and ovary and lowest expression in skeletal muscle.
Subcellular Localizations
Nucleus. Chromosome. Recruited on damaged DNA at sites of double-strand breaks.
Diseases
- Malignant Neoplasms
- Leukemia
- Chromosomal Translocation
- Situs Inversus
- Cell Transformation, Neoplastic
- Malignant Neoplasm Of Breast
- Carcinogenesis
- Leukemia, Myelocytic, Acute
- Acute Leukemia
- Neoplasms
Pathways
- Dna Repair
- Transposition
- Cell Proliferation
- Localization
- Mitosis
- Dna Integration
- Double-strand Break Repair
- Dna Replication
- Hypersensitivity
- Neurogenesis
- Histone Modification
- Metaphase
PTMs
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SETMAR
bosterbio.com/bosterbio-gene-info-cards/SETMAR
References
PMID: 16332963 by Lee S.-H., et al. The SET domain protein Metnase mediates foreign DNA integration and links integration to nonhomologous end-joining repair.
PMID: 16672366 by Cordaux R., et al. Birth of a chimeric primate gene by capture of the transposase gene from a mobile element.