This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
SLBP Antibodies
AND SLBP ELISA kits, SLBP Proteins
Many biological assays use antibodies to detect SLBP, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SLBP in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SLBP antibodies...
Previous: CBLIF
Next: ST8SIA4
SLBP Infographic by Boster Bio
All SLBP Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A02964-2
100 μg/vial
Cat # A02964-2
100 μg/vial
SLBP Overview
Facts about Histone RNA hairpin-binding protein.
Histone RNA hairpin-binding protein (SLBP)
RNA-binding protein included in the histone pre-mRNA processing. Binds the stem-loop structure of replication-dependent histone pre-mRNAs and leads to efficient 3'-end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), through the histone downstream element (HDE).
Plays an important role in targeting older histone mRNA from the nucleus to the cytoplasm and to the translation machinery. Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression.
Gene Information
| Human | |
|---|---|
| Gene Name: | SLBP |
| Uniprot: | Q14493 |
| Entrez: | 7884 |
Family
| Belongs to: |
|---|
| SLBP family |
Alternative Names
histone binding protein; histone RNA hairpin-binding protein; histone stem-loop binding protein; Histone stem-loop-binding protein; histone; stem-loop binding protein
Molecular Weight
Mass (kDA):
31.286 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4p16.3 |
| Sequence: | 4; NC_000004.12 (1692731..1715876, complement) |
Tissue Specificity
Widely expressed.
Subcellular Localizations
Cytoplasm. Nucleus. Polyribosome-associated. Localizes predominantly in the nucleus at the G1/G2 phases and the beginning of S phase. Through the S phase, partially redistributes to the cytoplasm. Binding to histone mRNA is necessary for cytoplasmic localization. Shuttles between the nucleus and the cytoplasm. Imported in the nucleus by the Importin alpha/Importin beta receptor.
Diseases
- Multiple Myeloma
- Stomach Neoplasms
- Carcinoma
- Carcinogenesis
- Malignant Neoplasms
- Cytomegalovirus Infections
- Headache
- Pain
- Liver Regeneration Disorder
- Microcephaly
- Epstein-barr Virus Infections
- Flexed Fetal Attitude
Interacting Proteins
- ERI1
- MIF4GD
- UPF1
Pathways
- Translation
- Cell Cycle
- S Phase
- Dna Replication
- Transport
- Oogenesis
- Rna Interference
- Mrna Processing
- Mitosis
- Oocyte Maturation
- Localization
- Nucleocytoplasmic Transport
- Fertilization
PTMs
- Cleavage
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLBP
bosterbio.com/bosterbio-gene-info-cards/SLBP
References
PMID: 1338771 by McCombie W.R., et al. Expressed genes, Alu repeats and polymorphisms in cosmids sequenced from chromosome 4p16.3.
PMID: 8957003 by Wang Z.-F., et al. The protein that binds the 3' end of histone mRNA: a novel RNA- binding protein required for histone pre-mRNA processing.