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- Table of Contents
1 Citations
Facts about Urea transporter 1.
The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it enables rapid equilibration between the lumen of the ducts and the interstitium, and thus prevents water loss driven by the high concentration of urea in the urine.
Human | |
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Gene Name: | SLC14A1 |
Uniprot: | Q13336 |
Entrez: | 6563 |
Belongs to: |
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urea transporter family |
FLJ33745; HsT1341; HUT11; JK; JKFLJ41687; RACH1; RACH2; SLC14A1; solute carrier family 14 (urea transporter), member 1 (Kidd blood group); Solute carrier family 14 member 1; truncated urea transporter; urea transporter 1; urea transporter JK glycoprotein; Urea transporter, erythrocyte; urea transporter-B1; UT1; UT1UT-B1; UT-B1; UTE; UTEblood group Kidd urea transporter
Mass (kDA):
42.528 kDA
Human | |
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Location: | 18q12.3 |
Sequence: | 18; NC_000018.10 (45724127..45752520) |
Detected in erythrocytes (at protein level). Erythrocytes.
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Restricted to the basolateral membrane in various portions of the urothelium.
This article will discuss the SLC superfamily, Boster Bio Anti-Urea transporter 1 Marker, and how this protein is involved in different human diseases. It will also discuss the biochemical and functional features of the SLC14A1 Marker and what types of studies it is effective for. The information presented here is applicable to all scientists worldwide. Boster Bio: Best Uses Of The SLC14A1 Marker
The anti-Urea transporter 1 SLC14a1 marker from Boster Bio was designed for use in WB applications. It recognizes the protein encoded by the gene. The protein transports urea in erythrocytes and is part of the Kidd antigen system. In addition to urea, this gene also transports several other solutes, including sodium, chloride, and glucose.
The Kidd protein urease transporter is an integral component of the RBC membrane. This transmembrane protein is predicted to span the membrane 10 times and to contain intracellular N and C termini. The Kidd protein is encoded by the SLC14A1 gene, which is located on chromosome 18 (18q12-q21). It consists of 11 exons and approximately 30 kbp of DNA. It has two major codominant alleles, which are separated by a single amino acid (Asn211).
The SLC superfamily is a cluster of proteins with many members. One of the families, SLC21, participates in the transport of long-chain fatty acids and has six members. Another family, SLC42, has two members and has functions in the transport of prostaglandins and steroid sulphates. These proteins are involved in a wide variety of biological processes, including the transport of various metabolites from the intestines into the blood.
The SLC superfamily includes 55 families, totaling 362 putatively functional protein-coding genes. Each member of the SLC superfamily has multiple transmembrane transporters and likely has endogenous substrates. In addition, drugs may 'hitchhike' on SLC transporters. Understanding the functions of these proteins is important for their potential use in genetics, pharmacology, and medicine.
Solute carrier membrane transport proteins (SLCs) control the movement of materials across cell membranes, and represent attractive targets for drug discovery and development. Of the many proteins involved in cell membrane transport, SLCs represent one of the largest families. Despite their importance, however, SLCs have been poorly characterized pharmacologically, and few chemicals have been proven effective or selective. This lack of understanding has spurred increased interest in the role of SLCs in various diseases and their potential therapeutic targets.
PMID: 7989337 by Olives B., et al. Cloning and functional expression of a urea transporter from human bone marrow cells.
PMID: 8573795 by Davey S., et al. RACH2, a novel human gene that complements a fission yeast cell cycle checkpoint mutation.
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