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We validate the specificity of these antibodies to SLC16A1 by testing them on tissues known to express SLC16A1 positively and negatively. Browse below to find the SLC16A1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.
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Facts about Monocarboxylate transporter 1.
Depending upon the tissue and on cicumstances, mediates the export or import of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet.
|major facilitator superfamily|
FLJ36745; HHF7; MCT 1; MCT; MCT1; MCT1MGC44475; member 1; monocarboxylate transporter 1; SLC16A1; Solute carrier family 16 member 1; solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
|Sequence:||1; NC_000001.11 (112911847..112956196, complement)|
Detected in heart and in blood lymphocytes and monocytes (at protein level). Widely expressed.
Cell membrane; Multi-pass membrane protein.
SLC16A1 (proton-coupled monocarboxylatetransporter) is a PXR target genetic. In sports performance, SLC16A1 can help predict race distance. Since 2000, researchers at Boster have been using this gene for athletes' genetic markers. Learn how to use SLC16A1 and other benefits.
The SLC16 solute carrier transporters are members of the major facilitator superfamily. These proteins have 12 transmembrane Helices and two 6-helix bundles that are linked by an intracellular loop. They are structurally related due to their perpendicular relationship to the substrate translocation pathway, membrane plane, and axis. This transporter has been identified with several pharmacologically relevant motifs. To characterize the pharmacological characteristics of the SLC16A1 monocarboxylate carrier, structural studies were conducted.
The SLC16A1 family of genes encodes the first four forms of the transporter. These transporters transport lactate, pyruvate, and other monocarboxylates. As cancer cells undergo a shift in metabolism from oxidative to highly-glycolytic, they accumulate lactate. SLC16A1 regulates the export of lactate by highly glycolytic cancer cells. It also plays a role in the metabolic interaction of cancer cells with cancer-associated cells.
The SLC16A1 genetic code encodes monocarboxylate transporter SLC16A1 which catalyzes rapid transfers across the plasma membrane. The SLC16A1 transporter is required for glucose homeostasis and normal nutrient assimilation in the brain, white adipose tissue, and skeletal muscle. It also regulates insulin secretion, regulates lactate levels, and contributes to central metabolic pathways.
The SLC16A family of membrane transport proteins is a diverse group that plays important roles in ATP transport within the body. Nearly every organ in the body has proton-coupled and other transporters. MCT8 and MCT10 are high-affinity amino acid transporters and thyroid hormone carriers. These proteins transport ATP in a proton-dependent, and Na+-independent way.
Studies of the SLC16A1 gene revealed that it was homozygous in the presence of an Xlinked PEST domain. This domain is located near the protein's N-terminal and is crucial to its function. The human MCT8 protein has two start sites. One is in the C-terminus while the other is in the N. Therefore, either of these sites would result in a functional protein.
Would you like to learn more about Boster Bio SLC16A1 Contact Sanbio for more information, custom services, and BeNeLux deliveries. Sanbio is a leader in the supply of bosteria-free PXR targets genes and can help you achieve the best results. Contact Sanbio to learn more about Boster Bio SLC16A1 and PXR targets.
Boster Bio is a leading manufacturer of antibodies and ELISA kits for immunological research. Boster Bio's portfolio includes over 12,000 antibodies. It also offers high-quality immunological products and kits for IHC/WB and flow. Each Boster bio antibody has been rigorously tested against over 250 tissue samples. Its antibodies are highly sensitive and robust, and are designed for optimal performance in a variety of applications.
The SLC16A1 genome contains polymorphisms, which can affect the activity of lactate transporter. Some of these genes can be up-regulated by training, which may be due adaptation to vigorous exercise. Interestingly, SNPs in the 5'UTR of SLC16A1 have been linked to greater chances of winning first place and competing in more races. These findings have provided a solid foundation for further research on the role of SLC16A1 in athletic performance.
The SLC16A1 gene has a strong association with athletic performance. Katarzyna Ropka Molik, along with colleagues, discovered a variety of novel polymorphisms, including missenses and 5'UTR variants, in the SLC16A1 genetic code. These polymorphisms were associated with both the number of races and the financial benefits. They also discovered that the race distance affected the distribution of genotypes. TT horses won short-distance races while GG and TG horses won long-distance races. Horses with two SLC16A1 gene variations had a higher percentage winning races and accumulated stakes.
Results from the study also suggest that SLC16A1 is a genetic factor for combat-sport athletes. The association between combat-sport and GABPb1 SNPs is based on combat-sport athletes' greater ability to respond to intermittent efforts. However, this association should not be taken as a definitive statement. It is important to note that SNPs in the GABPb 1 gene are highly related to combat-sport athletes.
MTC1 is also known for the SLC16A1 genes. Fast-fiber muscle cells produce lactate during intense exercise. When lactate reaches this level, it is transported out of the fast-fiber cells. Type I muscle fibers are slow-oxidative, and they take up lactate that is left behind by fast-fiber cell. The MCT1transporter facilitates the movement of lactate between the fast-fiber cells and these slow-oxidative fibers.
A novel polymorphism has been identified in the SLC16A1 gene in equine breeds. These polymorphisms include missense variants and 5'UTR variants. In this study, we found that the five'UTR variant was associated with both the number and financial benefits of races. We also found that the race distance affected how the genotype distribution was distributed. Short distance races were won by horses with genotypes TT, while middle and long distance races were won by GG or T. The number of winners among heterozygotes at long and middle distances increased from 19.5 to 27%.
The gene's SLC16A1 gene coding sequence was used to analyze the association between race performance traits and SLC16A1 gene expression. SLC16A1 was linked to race distance and sprint performance. We also examined the associations between SLC16A1 genotype polymorphisms (genes that are not related to race performance) and race performance in Arabian horses. The results of this study have been published in the journal Genetics and Molecular Biology.