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SLC7A6 Antibodies
AND SLC7A6 ELISA kits, SLC7A6 Proteins
Many biological assays use antibodies to detect SLC7A6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SLC7A6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SLC7A6 antibodies...
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SLC7A6 Overview
Facts about Y+L amino acid transporter 2.
Y+L amino acid transporter 2 (SLC7A6)
Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine.
Also functions as an arginine/glutamine exchanger, after an antiport mechanism for amino acid transport, influencing arginine discharge in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine.
Gene Information
| Human | |
|---|---|
| Gene Name: | SLC7A6 |
| Uniprot: | Q92536 |
| Entrez: | 9057 |
Family
| Belongs to: |
|---|
| amino acid-polyamine-organocation (APC) superfamily |
Alternative Names
Y+L amino acid transporter 2; LAT2; LAT-2; LAT3; SLC7A6; solute carrier family 7 (amino acid transporter light chain, y+L system), member 6; Y+LAT2; y+LAT-2
Molecular Weight
Mass (kDA):
56.828 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16q22.1 |
| Sequence: | 16; NC_000016.10 (68264510..68301819) |
Tissue Specificity
Expressed in normal fibroblasts and those from LPI patients. Also expressed in HUVECs, monocytes, RPE cells, and various carcinoma cell lines.
Subcellular Localizations
Basolateral cell membrane; Multi-pass membrane protein.
Diseases
- Lysinuric Protein Intolerance
- Malignant Neoplasms
- Carcinoma
- Neoplasms
- Adenocarcinoma
- Liver Carcinoma
- Neurotoxicity Syndromes
- Pulmonary Alveolar Proteinosis
- Aminoaciduria
- Head And Neck Carcinoma
- Endometrial Polyp
- Hyperammonemia
Pathways
- Transport
- Arginine Transport
- Amino Acid Transport
- Lactation
- Dna Repair
- Reverse Transcription
- Cell Growth
- Pathogenesis
- Tyrosine Transport
- Glomerular Filtration
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLC7A6
bosterbio.com/bosterbio-gene-info-cards/SLC7A6
References
PMID: 9829974 by Torrents D., et al. Identification and characterization of a membrane protein (y+L amino acid transporter-1) that associates with 4F2hc to encode the amino acid transport activity y+L. A candidate gene for lysinuric protein intolerance.
PMID: 11078698 by Dall'Asta V., et al. Arginine transport through system y(+)L in cultured human fibroblasts: normal phenotype of cells from LPI subjects.