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- Table of Contents
CCN family member 4 Antibodies
AND CCN4 ELISA kits, CCN family member 4 Proteins
Many biological assays use antibodies to detect CCN family member 4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CCN family member 4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CCN family member 4 antibodies...
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CCN4 Infographic by Boster Bio
All CCN4 Products
Product
Figures
Specificity
Applications
Price
Mouse
ELISA
$750
Cat # EK1195
96 wells/kit, with removable strips.
Cat # EK1195
96 wells/kit, with removable strips.
Human WISP1/CCN4 ELISA Kit PicoKine®
1 Citations 10 Q&As
Human
ELISA
$750
Cat # EK1204
96 wells/kit, with removable strips.
Cat # EK1204
96 wells/kit, with removable strips.
Rat
ELISA
$499
Cat # EK1588
96 wells/kit, with removable strips.
Cat # EK1588
96 wells/kit, with removable strips.
CCN4 Overview
Facts about CCN family member 4.
CCN family member 4 (CCN4)
Downstream regulator in the Wnt/Frizzled-signaling pathway.
Connected with cell survival.Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein.
Gene Information
| Human | |
|---|---|
| Gene Name: | CCN4 |
| Uniprot: | O95388 |
| Entrez: | 8840 |
Family
| Belongs to: |
|---|
| CCN family |
Alternative Names
CCN family member 4; CCN4; CCN4WISP1tc; WISP1; WISP-1; WISP1c; WISP1i; WNT1 induced secreted protein 1; WNT1 inducible signaling pathway protein 1; Wnt-1 inducible signaling pathway protein 1; wnt-1 signaling pathway protein 1; Wnt-1-induced secreted protein; WNT1-inducible-signaling pathway protein 1
Molecular Weight
Mass (kDA):
40.331 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8q24.22 |
| Sequence: | 8; NC_000008.11 (133190907..133231690) |
Tissue Specificity
Expressed in heart, kidney, lung, pancreas, placenta, ovary, small intestine and spleen. Isoform 2 is expressed predominantly in scirrhous gastric carcinoma and, weakly in placenta. Overexpression is associated with several cancers including breast cancer and colon tumors. Isoform 2 is overexpressed in scirrhous gastric carcinoma.
Subcellular Localizations
Secreted.
Diseases
- Neoplasms
- Malignant Neoplasms
- Cell Transformation, Neoplastic
- Tissue Adhesions
- Carcinoma
- Neoplasm Metastasis
- Tumor Angiogenesis
- Cell Invasion
- Colorectal Cancer
- Nephroblastoma
- Fibrosis
- Mammary Neoplasms
- Inflammation
Pathways
- Cell Proliferation
- Angiogenesis
- Pathogenesis
- Cell Growth
- Cell Adhesion
- Cell Death
- Secretion
- Cell Differentiation
- Fibroblast Proliferation
- Ossification
- Chondrocyte Differentiation
- Aging
- Cell Fate Determination
PTMs
- Phosphorylation
Research Areas
- Apoptosis
- Cancer
- DNA Repair
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CCN4
bosterbio.com/bosterbio-gene-info-cards/CCN4
References
PMID: 9843955 by Pennica D., et al. WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors.
PMID: 11571650 by Tanaka S., et al. A novel variant of WISP1 lacking a Von Willebrand type C module overexpressed in scirrhous gastric carcinoma.
2 Publications of Boster CCN family member 4 Antibodies & ELISA Kits
- PubMed ID: , Wisp1 is a circulating factor that stimulates proliferation of adult mouse and h...
- PubMed ID: 33239617, Fernandez-Ruiz R,García-Alamán A,Esteban Y,Mir-Coll J,Serra-Navarro B,Fontcube...
*More publications can be found for each product on its corresponding product page