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- Table of Contents
Facts about Protein SMG5.
Promotes dephosphorylation of UPF1. Together with SMG7 is believed to give a link to the mRNA degradation machinery involving exonucleolytic pathways, and to function as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation.
| Human | |
|---|---|
| Gene Name: | SMG5 |
| Uniprot: | Q9UPR3 |
| Entrez: | 23381 |

| Belongs to: |
|---|
| No superfamily |

EST1BFLJ12287; EST1-like protein B; Est1p-like protein B; ever shorter telomeres 1B; hSMG-5; KIAA1089FLJ34864; LPTS interacting protein; LPTS-interacting protein; LPTSRP1; LPTS-RP1EST1 telomerase component homolog B; protein SMG5; RP11-54H19.7; SMG-5 homolog; Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans); SMG-5
Mass (kDA):
113.928 kDA

| Human | |
|---|---|
| Location: | 1q22 |
| Sequence: | 1; NC_000001.11 (156249224..156291498, complement) |
Ubiquitous.
Cytoplasm. Nucleus. Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm. Detected in cytoplasmic mRNA decay bodies.






PMID: 14636577 by Ohnishi T., et al. Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7.
PMID: 12699629 by Snow B.E., et al. Functional conservation of the telomerase protein Est1p in humans.