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SNRPE Antibodies
AND SNRPE ELISA kits, SNRPE Proteins
Many biological assays use antibodies to detect SNRPE, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SNRPE in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SNRPE antibodies...
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SNRPE Infographic by Boster Bio
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SNRPE Overview
Facts about Small nuclear ribonucleoprotein E.
Small nuclear ribonucleoprotein E (SNRPE)
Plays role in pre-mRNA splicing as core part of this SMN-Sm complex that mediates spliceosomal snRNP assembly and as part of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:23246290, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Part of the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346).
Is also a part of the minor U12 spliceosome (PubMed:15146077). Included in the U7 snRNP it is involved in histone 3'-end processing (PubMed:12975319).
Gene Information
| Human | |
|---|---|
| Gene Name: | SNRPE |
| Uniprot: | P62304 |
| Entrez: | 6635 |
Family
| Belongs to: |
|---|
| snRNP Sm proteins family |
Alternative Names
B-raf; Sm protein E; small nuclear ribonucleoprotein E; small nuclear ribonucleoprotein polypeptide E; SmE; Sm-ESME; snRNP-E
Molecular Weight
Mass (kDA):
10.804 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q32.1 |
| Sequence: | 1; NC_000001.11 (203861599..203871152) |
Tissue Specificity
Widely expressed. In scalp skin, it is present in the hair follicle, the epidermis, and the dermis.
Subcellular Localizations
Cytoplasm, cytosol. Nucleus. SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Lupus Erythematosus, Systemic
- Growth Retardation
- Autoimmunity
- Ataxia
- Hydrocephalus
- Infertility
- Malignant Neoplasm Of Lung
- Carcinogenesis
- Nonalcoholic Steatohepatitis
Interacting Proteins
- GEMIN5
- GEMIN6
- LSM2
- SF3A2
- SNRPF
- SNRPG
Pathways
- Pathogenesis
- Transport
- Cell Proliferation
- Mrna Splicing
- Translation
- S Phase
- Cell Growth
- Regulation Of Gene Expression
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SNRPE
bosterbio.com/bosterbio-gene-info-cards/SNRPE
References
PMID: 2974536 by Stanford D.R., et al. The complete primary structure of the human snRNP E protein.
PMID: 2972723 by Stanford D.R., et al. The small nuclear ribonucleoprotein E protein gene contains four introns and has upstream similarities to genes for ribosomal proteins.