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- Table of Contents
Facts about Protein spire homolog 1.
Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis.
Human | |
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Gene Name: | SPIRE1 |
Uniprot: | Q08AE8 |
Entrez: | 56907 |
Belongs to: |
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spire family |
KIAA1135; MGC150621; MGC150622; protein spire homolog 1; SPIR1; Spir-1; spire homolog 1 (Drosophila)
Mass (kDA):
85.544 kDA
Human | |
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Location: | 18p11.21 |
Sequence: | 18; NC_000018.10 (12446512..12661814, complement) |
Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion (By similarity). Punctate spots in perinuclear region and cytoplasm, colocalized with Rab11 (By similarity).
PMID: 11747823 by Kerkhoff E., et al. The Spir actin organizers are involved in vesicle transport processes.
PMID: 21620703 by Pfender S., et al. Spire-type actin nucleators cooperate with Formin-2 to drive asymmetric oocyte division.