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Speckle-type POZ protein Antibodies
AND SPOP ELISA kits, Speckle-type POZ protein Proteins
Many biological assays use antibodies to detect Speckle-type POZ protein, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Speckle-type POZ protein in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Speckle-type POZ protein antibodies...
Designing a Western blot for Speckle-type POZ protein? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SPOP Western Blot GuideSPOP Infographic by Boster Bio
All SPOP Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
ELISA, Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # A14169-1
100 μg/vial
Cat # A14169-1
100 μg/vial
SPOP Overview
Facts about Speckle-type POZ protein.
Speckle-type POZ protein (SPOP)
Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3.
In complex with CUL3, involved in ubiquitination of H2AFY and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation.
Gene Information
| Human | |
|---|---|
| Gene Name: | SPOP |
| Uniprot: | O43791 |
| Entrez: | 8405 |
Family
| Belongs to: |
|---|
| Tdpoz family |
Alternative Names
HIB homolog 1; Roadkill homolog 1; speckle-type POZ protein; TEF2
Molecular Weight
Mass (kDA):
42.132 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q21.33 |
| Sequence: | 17; NC_000017.11 (49598884..49678163, complement) |
Tissue Specificity
Widely expressed.
Subcellular Localizations
Nucleus. Nucleus speckle.
Diseases
- Malignant Neoplasms
- Neoplasms
- Cell Transformation, Neoplastic
- Diabetes Mellitus
- Insulinoma
- Scleroderma
- Mammary Neoplasms
- Malignant Neoplasm Of Prostate
- Prostatic Neoplasms
- Leukoencephalopathy, Progressive Multifocal
- Neoplasm Metastasis
- Malnutrition
Interacting Proteins
- CUL3
- DAXX
- DUSP7
- MYD88
- NCOA3
- PTEN
Pathways
- Localization
- Glucose Homeostasis
- Transport
- Histone Deacetylation
- Pancreas Development
- Induction Of Apoptosis
- Fertilization
- Dna Methylation
- Proteolysis
- Methylation
- Cell Cycle
- Sperm Capacitation
PTMs
- Ubiquitination
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SPOP
bosterbio.com/bosterbio-gene-info-cards/SPOP
References
PMID: 9414087 by Nagai Y., et al. Identification of a novel nuclear speckle-type protein, SPOP.
PMID: 14528312 by Furukawa M., et al. Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases.