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- Table of Contents
Facts about Speckle-type POZ protein.
In complex with CUL3, involved in ubiquitination of H2AFY and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation.
Human | |
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Gene Name: | SPOP |
Uniprot: | O43791 |
Entrez: | 8405 |
Belongs to: |
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Tdpoz family |
HIB homolog 1; Roadkill homolog 1; speckle-type POZ protein; TEF2
Mass (kDA):
42.132 kDA
Human | |
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Location: | 17q21.33 |
Sequence: | 17; NC_000017.11 (49598884..49678163, complement) |
Widely expressed.
Nucleus. Nucleus speckle.
Spopl can be detected in biological samples using high-affinity primary antibody to it. These antibodies may be monoclonal or polyclonal and can react with Spopl in a variety of samples. For example, Boster Bio uses rabbit and mouse to develop its Spopl antibodies. These antibodies will recognize Spopl found in samples from different species.
Boster Bio primary antibodies are able to detect Spopl accurately in tissues, cells, and samples. These antibodies have been tested in IP, WB, and IHC and are highly cited and trusted by researchers around the world. Boster antibodies have been validated for use in Western Blotting and Immunohistochemistry, and are available in Liquid and powder forms.
Boster Bio is an international supplier of recombinant enzymes and antibodies that have been validated using multiple methods, including Western Blotting and Immunohistochemistry. Their portfolio includes viral agents, transfected cells, and recombinant and DNA particle products. They also offer recombinant enzymes and antibodies as well as biochemical assays for the life science industry.
Recombinant enzyme complexes for the SpoP marker are available from Boster Bio. These products can be used in research and development. The SPOP marker is a protein that plays a role in the metabolism sugars and amino acid. Scientists can detect SPOP using recombinant protein complexes in blood, urine, and tissue samples.
PMID: 9414087 by Nagai Y., et al. Identification of a novel nuclear speckle-type protein, SPOP.
PMID: 14528312 by Furukawa M., et al. Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases.