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- Table of Contents
Facts about Double-stranded RNA-binding protein Staufen homolog 2.
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Human | |
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Gene Name: | STAU2 |
Uniprot: | Q9NUL3 |
Entrez: | 27067 |
Belongs to: |
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No superfamily |
DKFZp781K0371,39K2; double-stranded RNA-binding protein Staufen homolog 2,39K3; MGC119606; staufen (Drosophila, RNA-binding protein) homolog 2; staufen homolog 2; staufen, RNA binding protein, homolog 2 (Drosophila)
Mass (kDA):
62.608 kDA
Human | |
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Location: | 8q21.11 |
Sequence: | 8; NC_000008.11 (73420369..73747708, complement) |
Cytoplasm. Nucleus. Nucleus, nucleolus. Endoplasmic reticulum. Shuttles between the nucleolus, nucleus and the cytoplasm. Nuclear export of isoform 1 is independent of XPO1/CRM1 and requires the exportin XPO5. Nuclear export of isoform 2 and isoform 3 can occur by both XPO1/CRM1-dependent and XPO1/CRM1-independent pathways. Found in large cytoplasmic ribonucleoprotein (RNP) granules which are present in the actin rich regions of myelinating processes and associated with microtubules, polysomes and the endoplasmic reticulum. Also recruited to stress granules (SGs) upon inhibition of translation
PMID: 10585778 by Buchner G., et al. Identification of a novel homolog of the Drosophila staufen protein in the chromosome 8q13-q21.1 region.
PMID: 12140260 by Duchaine T.F., et al. Staufen2 isoforms localize to the somatodendritic domain of neurons and interact with different organelles.