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- Table of Contents
Facts about Bile salt sulfotransferase.
Human | |
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Gene Name: | SULT2A1 |
Uniprot: | Q06520 |
Entrez: | 6822 |
Belongs to: |
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sulfotransferase 1 family |
alcohol/hydroxysteroid sulfotransferase; Cytosolic Sulfotransferase 2A1; Dehydroepiandrosterone sulfotransferase; DHEAS; DHEA-ST; DHEA-STbile salt sulfotransferase; EC 2.8.2.14; HST; hSTa; Hydroxysteroid Sulfotransferase; ST2; ST2A1; ST2A3; STDbile-salt sulfotranasferase 2A1; Sulfotransferase 2A1; sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone(DHEA)-preferring, member 1; SULT2A1
Mass (kDA):
33.78 kDA
Human | |
---|---|
Location: | 19q13.33 |
Sequence: | 19; NC_000019.10 (47870467..47886315, complement) |
Liver, adrenal and at lower level in the kidney. Is present in human fetus in higher level in the adrenal than the liver and the kidney.
Cytoplasm.
Boster Bio sells this anti-Bile sulfotransferase antibody in their catalog. This particular antibody is suitable for flow cytometry (IF) and IF. It reacts to both Rat and Human cells. Learn more about the boster bio antibody's benefits. The Boster Bio Anti-Bile Salt Sulfotransferase SULT2A1 antibody.
SULT2A1 can catalyze the sulfation and is a member in the hydroxysteroid sulfotransferase - HSS subfamily. This process results in inactive sulfur conjugates that can be transported and converted to biologically active steroids using a sulfatase pathway. During pig implantation SULT2A1 gene expression was increased in uterine fluid. This could be a result of estrogen homeostasis, steroidogenesis, and increased SULT2A1 expression.
Moreover, SULT2A1 is involved in the progression of tumors, and the cellular transformation from epithelium to mesenchymal tissue occurs due to the involvement of apoptosis. Moreover, SULT2A1 was associated with poor prognosis for women with this mutation.
It is unclear what role SULT2A1 has in the progression ovarian tumors. In fact, researchers have questioned the role of SULT2A1 in the process of ovarian development. The authors concluded that this gene may not be responsible for ovarian cancer. This conclusion is further supported with the fact that SULT2A1 has been found in the epithelium of the endometrium, which is located close to conceptus.
The GSHC results revealed that SULT2A1 is abundantly expressed within the endometrial epithelia near the conceptus. Although its role in fetal growth remains unclear, SULT2A1 can be found in the endometrialluminal epithelium.
SULT2A1 plays a crucial role in fetal and fetal development. It has also been associated to cystic fibrosis. It has also been shown negatively to regulate autophagy as well as CFTR function. These results suggest that CFTR can be linked to SULT2A1's expression in the endometrial lumen epithelium.
A study revealed that there is a missing protein in the area of the conceptus in the endometrial lumen epithelia. MEP1B, which is essential to myelination of the node Ranvier and the integrity the peripheral nerve system's peripheral nervous system, is the missing protein. According to an analysis done by POLLARD J.W. NIKLAUS A.L.
These results support previous studies which have shown that MEP1B was absent from epithelial cells near the conceptus. The study was published online in the journal Amj. Respir. Cell Mol Biol is a reflection of the recent findings by the RAMSEY and TAYLOR labs. Their findings provide evidence of the missing chemokines, and the missing MEP1B, according to the authors.
These findings also support the hypothesis that MEP1B is entirely absent in the endometrial luminal lining in proximity to the conceptus. The MEP1B gene is also absent in the epithelial luminal lining of the conceptus, suggesting that MEP1B may be essential in regulating the development of embryonic stem cells.
The elongation of a conceptus in domestic animals is closely related to the implantation of that same conceptus. The conceptus is affected by several processes during pregnancy. These include the posthatching of the blastocyst, elongation or the conceptus, as well as the suppression of the endometrial and luteolytic mechanisms. The conceptus experiences an exponential increase in trophectoderm. Progesterone also regulates the expression of genes involved in elongation and implantation of the conceptus.
The MEP1B genes is key to the regulation of human uterus development. Although the MEP1B gene has been shown to be involved in the development ovaries it is not found in uterine cells that are close to the conceptus. The MEP1B gene expression can help to understand the human uterine line in close proximity to and within the conceptus.
The MEP1B genetic factor also plays a critical role in endometrial cell growth. MEP1B's absence in the embryo's endometrial luminal epithelium in close proximity to it can cause it to stop growing. MEP1B is essential to maintain the elongation, but it is absent in the endometrial lumen epithelium near the conceptus.
MEP1B not only promotes endometrial development, but also promotes gene expression that is involved in cell attachment and migration. It also induces the release of fatty acid binding proteins 3 and zinc metaloendopeptidase A, as well as candidate cells nt ulmlproteiilactor als. Howe SULTt incls is kclosonlycble tann cmr
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SULTB has enehighxpressed with the conceptus.
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PMID: 7678732 by Comer K.A., et al. Cloning and expression of human liver dehydroepiandrosterone sulphotransferase.
PMID: 1588921 by Otterness D.M., et al. Human liver dehydroepiandrosterone sulfotransferase: molecular cloning and expression of cDNA.