SH2B adapter protein 1 (Sh2b1)

Adapter protein for several members of the tyrosine kinase receptor family. Involved in several signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, such as the receptors of insulin (INS), insulin-like growth factor I (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs).

In growth hormone (GH) signaling, autophosphorylated ('Tyr-813') JAK2 recruits SH2B1, which in turn is phosphorylated by JAK2 on tyrosine residues. These phosphotyrosines form possible binding sites for other signaling proteins.