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- Table of Contents
TBX5 Antibodies
AND TBX5 ELISA kits, TBX5 Proteins
Many biological assays use antibodies to detect TBX5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TBX5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TBX5 antibodies...
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TBX5 Infographic by Boster Bio
All TBX5 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, WB
$370
Cat # A00803-3
100 μg/vial
Cat # A00803-3
100 μg/vial
TBX5 Overview
Facts about T-box transcription factor TBX5.
T-box transcription factor TBX5 (TBX5)
DNA-binding protein which regulates the transcription of several genes and is involved in heart development and limb pattern formation (PubMed:25725155, PubMed:25963046, PubMed:29174768, PubMed:26917986, PubMed:27035640, PubMed:8988164). Binds to the core DNA motif of NPPA promoter (PubMed:26926761).
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Gene Information
| Human | |
|---|---|
| Gene Name: | TBX5 |
| Uniprot: | Q99593 |
| Entrez: | 6910 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
HOS; T-box 5; T-box protein 5; T-box transcription factor TBX5; TBX5
Molecular Weight
Mass (kDA):
57.711 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q24.21 |
| Sequence: | 12; NC_000012.12 (114353911..114408708, complement) |
Subcellular Localizations
Nucleus. Cytoplasm. Shuttles between the cytoplasm and the nucleus. Acetylation at Lys-339 promotes nuclear retention.
Diseases
- Holt-oram Syndrome
- Congenital Heart Defects
- Heart Diseases
- Congenital Heart Disease
- Limb Deformities, Congenital
- Congenital Abnormality
- Haploinsufficiency
- Heart Septal Defects
- Atrial Septal Defects
- Limb Defect
- Ventricular Septal Defects
- Congenital Hand Deformities
- Endocardial Cushion Defects
Interacting Proteins
- Gata4
- NKX2-5
- YAP1
Pathways
- Heart Development
- Limb Development
- Localization
- Heart Formation
- Cell Proliferation
- Cardiac Conduction
- Regeneration
- Pathogenesis
- Heart Morphogenesis
- Eye Development
- Fin Development
- Cell Differentiation
- Gastrulation
PTMs
- Phosphorylation
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TBX5
bosterbio.com/bosterbio-gene-info-cards/TBX5
References
PMID: 8988164 by Li Q.Y., et al. Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family.
PMID: 8988165 by Basson C.T., et al. Mutations in human TBX5 cause limb and cardiac malformation in Holt- Oram syndrome.