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- Table of Contents
TIA1 Antibodies
AND TIA1 ELISA kits, TIA1 Proteins
Many biological assays use antibodies to detect TIA1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TIA1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TIA1 antibodies...
Designing a Western blot for TIA1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the TIA1 Western Blot GuideTIA1 Infographic by Boster Bio
All TIA1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
WB
$370
Cat # PA2194
100 μg/vial
Cat # PA2194
100 μg/vial
Human, Mouse, Rat
ELISA
$540
Cat # EKC2630
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2630
1 kit, containing two 96-well plates and all necessary reagents
TIA1 Overview
Facts about Nucleolysin TIA-1 isoform p40.
Nucleolysin TIA-1 isoform p40 (TIA1)
Involved in other pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte cells.
May be involved in apoptosis. .
Gene Information
| Human | |
|---|---|
| Gene Name: | TIA1 |
| Uniprot: | P31483 |
| Entrez: | 7072 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
cytotoxic granule-associated RNA-binding protein; nucleolysin TIA-1 isoform p40; p40-TIA-1 (containing p15-TIA-1); p40-TIA-1; RNA-binding protein TIA-1; T-cell-restricted intracellular antigen-1; TIA1 cytotoxic granule-associated RNA binding protein; TIA1 cytotoxic granule-associated RNA-binding protein; TIA-1
Molecular Weight
Mass (kDA):
42.963 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2p13.3 |
| Sequence: | 2; NC_000002.12 (70209444..70248793, complement) |
Subcellular Localizations
Cytoplasm, Stress granule. Nucleus. Accumulates in cytoplasmic stress granules (SG) following cellular damage.
Diseases
- Lymphoma
- Neoplasms
- T-cell Lymphoma
- Malignant Neoplasms
- Diffuse Large B-cell Lymphoma
- Ki-1+ Anaplastic Large Cell Lymphoma
- Hodgkin Disease
- Epstein-barr Virus Infections
- Transient Ischemic Attack
- Peripheral T-cell Lymphoma
- Skin Neoplasms
- B-cell Lymphomas
Interacting Proteins
- SNRNP70
- SNRPA
- SNRPC
Pathways
- Translation
- Pathogenesis
- Immune Response
- Localization
- Cell Death
- Cell Proliferation
- Transport
- Programmed Cell Death
- Response To Oxidative Stress
- Response To Stress
- Dna Repair
- Hypersensitivity
- Inflammatory Response
PTMs
- Phosphorylation
- Cleavage
- Dephosphorylation
Research Areas
- Adaptive Immunity
- Apoptosis
- Immunology
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TIA1
bosterbio.com/bosterbio-gene-info-cards/TIA1
References
PMID: 1934064 by Tian Q., et al. A polyadenylate binding protein localized to the granules of cytolytic lymphocytes induces DNA fragmentation in target cells.
PMID: 8176212 by Kawakami A., et al. Intron-exon organization and chromosomal localization of the human TIA-1 gene.