Tryptase alpha/beta-1 Antibodies

AND TPSAB1 ELISA kits, Tryptase alpha/beta-1 Proteins

Many biological assays use antibodies to detect Tryptase alpha/beta-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Tryptase alpha/beta-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Tryptase alpha/beta-1 antibodies...

We validate the specificity of these antibodies to Tryptase alpha/beta-1 by testing them on tissues known to express TPSAB1 positively and negatively. Browse below to find the TPSAB1 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TPSAB1 Infographic by Boster Bio

All TPSAB1 Products

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Anti-Mast Cell Tryptase/TPSAB1 Antibody Picoband®

2 Q&As

Western blot analysis of Mast Cell Tryptase using anti-Mast Cell Tryptase antibody (PB10016)

IHC analysis of Mast Cell Tryptase using anti-Mast Cell Tryptase antibody (PB10016)

Human

IHC, WB, ELISA (Cap)

$370
Cat # PB10016
100 μg/vial

Anti-Mast Cell Tryptase Rabbit Monoclonal Antibody

5 Q&As

Western blot analysis of Mast Cell Tryptase expression in Human tonsil lysate

Immunohistochemical analysis of paraffin-embedded human kidney, using Mast Cell Tryptase Antibody

Human, Mouse, Rat

IP, IHC, WB

$370
Cat # M08039
100 μl

Anti-Tryptase alpha/beta-1 TPSAB1 Antibody

Western blot analysis of extracts of Rat skin, using TPSAB1 antibody at 1:1000 dilution

Western blot analysis of extracts of Mouse skin, using TPSAB1 antibody at 1:1000 dilution

Human, Mouse, Rat

$405
Cat # A08039
100ul

Anti-Tryptase Alpha / Beta 1 TPSAB1 Antibody

Western blot analysis of Mast Cell Tryptase on human skin lysates using anti-Mast Cell Tryptase antibody at 1/1,000 dilution

Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-Mast Cell Tryptase antibody

Human, Mouse, Rat

IP, IHC, WB

$405
Cat # A08039-1
100ul

TPSAB1 (NM_003294) Human Over-expression Lysate

Human

$628
Cat # LS007177
20 µg, 100 µg

TPSAB1 Overview

Facts about Tryptase alpha/beta-1.

TPSAB1 3D structure. Source: alphafold

Tryptase alpha/beta-1 (TPSAB1)

Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of the cell type. May play a role in innate immunity.

Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates (PubMed:18854315). .

Gene Information

Human
Gene Name:	TPSAB1
Uniprot:	Q15661
Entrez:	7177

Family

Belongs to:

peptidase S1 family

Alternative Names

alpha-Tryptase; TPS1; TPS2; TPSAB1; TPSB1; Tryptase 1; Tryptase alpha; tryptase alpha/beta 1

Molecular Weight

Mass (kDA):
30.515 kDA

Genomic Context


Human

Location:	16p13.3
Sequence:	16; NC_000016.10 (1240705..1242554)

Tissue Specificity

Isoform 1 and isoform 2 are expressed in lung, stomach, spleen, heart and skin; in these tissues, isoform 1 is predominant. Isoform 2 is expressed in aorta, spleen, and breast tumor, with highest levels in the endothelial cells of some blood vessels surrounding the aorta, as well as those surrounding the tumor and low levels, if any, in mast cells (at protein level).

Subcellular Localizations

Secreted. Released from the secretory granules upon mast cell activation.

Diseases

Inflammation
Anaphylaxis
Asthma
Mastocytosis
Hyperplasia
Fibrosis
Neoplasms
Inflammatory Response
Allergy
Tumor Angiogenesis
Bronchial Hyperreactivity
Edema

Patient Dependence On
Leukemia
Muscular Dystrophy, Duchenne
Malignant Neoplasms
Rheumatoid Arthritis
Pathologic Neovascularization
Trichinellosis

Interacting Proteins

NCK1
PIK3R1

Pathways

Cell Activation
Anaphylaxis
Pathogenesis
Mast Cell Activation
Secretion
Proteolysis
Inflammatory Response
Cell Differentiation
Hypersensitivity
Cell Development
Coagulation
Mast Cell Differentiation
Angiogenesis

Cell Maturation
Translation
Exocytosis
Mast Cell Degranulation
Tissue Remodeling
Cell Growth
Regulation Of Angiogenesis

PTMs

Cleavage
Phosphorylation
Glycosylation

Sulphation
Methylation
Myristoylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TPSAB1

References

PMID: 2677049 by Miller J.S., et al. Cloning and characterization of complementary DNA for human tryptase.

PMID: 2187193 by Vanderslice P., et al. Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family.

2 Publications of Boster Tryptase alpha/beta-1 Antibodies & ELISA Kits

PubMed ID: 24735816, Tryptase inhibitor APC 366 prevents hepatic fibrosis by inhibiting collagen synt...
PubMed ID: 30090343, Acute exposure of ozone induced pulmonary injury and the protective role of vita...

*More publications can be found for each product on its corresponding product page