Twinkle protein, mitochondrial (TWNK)

Involved in mitochondrial DNA (mtDNA) metabolism. Could function as an adenine nucleotide-dependent DNA helicase.

Function inferred to be crucial for life maintenance of mtDNA integrity. In vitro, forms in conjunction with POLG, a processive replication machinery, which can use double-stranded DNA (dsDNA) as template to synthesize single-stranded DNA (ssDNA) molecules.