Tyrosine-protein kinase TXK (TXK)

Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the evolution, function and differentiation of conventional T- cells and nonconventional NKT-cells.

When antigen presenting cells (APC) activate T-cell receptor (TCR), a collection of phosphorylation lead to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation.