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- Table of Contents
TSPO Antibodies
AND TSPO ELISA kits, TSPO Proteins
Many biological assays use antibodies to detect TSPO, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TSPO in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TSPO antibodies...
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TSPO Infographic by Boster Bio
All TSPO Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M01153
100 μl
Cat # M01153
100 μl
TSPO Overview
Facts about Putative peripheral benzodiazepine receptor-related protein.
Putative peripheral benzodiazepine receptor-related protein (TSPO)
Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Promotes the transfer of cholesterol across mitochondrial membranes and might play a role in lipid metabolism (PubMed:24814875), but its exact physiological function is controversial.
It's apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral-type benzodiazepine receptor; may also bind isoquinoline carboxamides (PubMed:1847678).
Gene Information
| Human | |
|---|---|
| Gene Name: | TSPO |
| Uniprot: | B1AH88 |
| Entrez: | 706 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
benzodiazepine peripheral binding site; BZRPDBI; IBP; MBRPBS; mDRC; Mitochondrial benzodiazepine receptor; PBR; PBRBPBS; PBRS; peripheral benzodiazepine receptor; Peripheral-type benzodiazepine receptor; pk18; PKBSbenzodiazapine receptor (peripheral); PTBR; translocator protein (18kDa); translocator protein; TSPO
Molecular Weight
Mass (kDA):
10.537 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 22q13.2 |
| Sequence: | 22; NC_000022.11 (43151559..43163242) |
Tissue Specificity
Ubiquitous.
Diseases
- Inflammation
- Malignant Neoplasms
- Neoplasms
- Glioma
- Brain Injuries
- Anxiety Disorders
- Neurodegenerative Disorders
- Ischemia
- Nervousness
- Malignant Neoplasm Of Breast
- Cerebrovascular Accident
- Nerve Degeneration
- Alzheimer's Disease
Pathways
- Transport
- Cell Proliferation
- Cell Death
- Cholesterol Transport
- Localization
- Cell Growth
- Regeneration
- Cholesterol Import
- Pathogenesis
- Neuroprotection
- Secretion
- Inflammatory Response
- Excretion
PTMs
- Cleavage
- Oxidation
- Phosphorylation
- Methylation
Research Areas
- Cancer
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TSPO
bosterbio.com/bosterbio-gene-info-cards/TSPO
References
PMID: 8307574 by Lin D., et al. The human peripheral benzodiazepine receptor gene: cloning and characterization of alternative splicing in normal tissues and in a patient with congenital lipoid adrenal hyperplasia.