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- Table of Contents
Facts about Ubiquitin-conjugating enzyme E2 G1.
May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4.
Human | |
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Gene Name: | UBE2G1 |
Uniprot: | P62253 |
Entrez: | 7326 |
Belongs to: |
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ubiquitin-conjugating enzyme family |
E217K; EC 6.3.2.19; UBC7; UBE2G1; UBE2GE217K; Ubiquitin carrier protein G1; ubiquitin-conjugating enzyme E2 G1; ubiquitin-conjugating enzyme E2G 1 (homologous to C. elegans UBC7); ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans); ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast); Ubiquitin-protein ligase G1
Mass (kDA):
19.509 kDA
Human | |
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Location: | 17p13.2 |
Sequence: | 17; NC_000017.11 (4269217..4366674, complement) |
Widely expressed, mainly in skeletal muscle.
PMID: 8893823 by Watanabe T.K., et al. Molecular cloning of UBE2G, encoding a human skeletal muscle-specific ubiquitin-conjugating enzyme homologous to UBC7 of C. elegans.
PMID: 19103148 by Pabarcus M.K., et al. CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases.