URI1 Antibodies

AND URI1 ELISA kits, URI1 Proteins

Many biological assays use antibodies to detect URI1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with URI1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop URI1 antibodies...

We validate the specificity of these antibodies to URI1 by testing them on tissues known to express URI1 positively and negatively. Browse below to find the URI1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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URI1 Infographic by Boster Bio

All URI1 Products

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C19orf2 (URI1) (NM_003796) Human Over-expression Lysate

Human

$960
Cat # LS008725
20 µg, 100 µg

Anti-C19orf2/URI1 Antibody Picoband®

Flow Cytometry analysis of RT4 cells using anti-C19orf2/URI1 antibody (A05245-2)

Western blot analysis of C19orf2/URI1 using anti-C19orf2/URI1 antibody (A05245-2)

Human, Mouse

ELISA, Flow Cytometry, WB

$370
Cat # A05245-2
100 µg/vial

URI1 Overview

Facts about Unconventional prefoldin RPB5 interactor 1.

URI1 3D structure. Source: alphafold

Unconventional prefoldin RPB5 interactor 1 (URI1)

Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription.

May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent development in prostate cancer cells. Required for cell survival in ovarian cancer cells.

Gene Information

Human
Gene Name:	URI1
Uniprot:	O94763
Entrez:	8725

Family

Belongs to:

RNA polymerase II subunit 5-mediating protein family

Alternative Names

chromosome 19 open reading frame 2; FLJ10575; NNX3RPB5-mediating protein; Protein NNX3; RMPunconventional prefoldin RPB5 interactor; RNA polymerase II subunit 5-mediating protein; URIRNA polymerase II, subunit 5-mediating protein

Molecular Weight

Mass (kDA):
59.832 kDA

Genomic Context


Human

Location:	19q12
Sequence:	19; NC_000019.10 (29923650..30016612)

Tissue Specificity

Ubiquitous. Expressed in ovarian cancers (at protein level). Expressed strongly in skeletal muscle. Expressed weakly in brain, heart, pancreas and in prostate epithelial cells.

Subcellular Localizations

Nucleus. Cytoplasm. Mitochondrion. Cell projection, dendrite. Colocalizes with PFDN2, PFDN4, PPP1CC, RPS6KB1 and STAP1 at mitochondrion.

Diseases

Upper Respiratory Infections
Hepatitis B
Neoplasms
Hepatitis
Adenoma
Malignant Neoplasms
Cholangiocarcinoma
Adrenal Hyperplasia
Neoplasms, Experimental
Carcinoma
Pyotraumatic Dermatitis
Adenoma, Chromophobe

Pituitary Diseases
Lymphoma
Malignant Neoplasm Of Ovary
Pituitary Neoplasms
Ovarian Neoplasm
Dysequilibrium Syndrome
Adenoma, Acidophil

Interacting Proteins

Ahr
Esr1
GTF2F1
GTF2F2
OGT

PFDN2
POLR2E
PPP1CC
RPAP3

Pathways

Cell Growth
Localization
Mismatch Repair
Translation
Cell Cycle

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/URI1

References

PMID: 9878255 by Van Leuven F., et al. Molecular cloning of a gene on chromosome 19q12 coding for a novel intracellular protein: analysis of expression in human and mouse tissues and in human tumor cells, particularly Reed-Sternberg cells in Hodgkin disease.

PMID: 9819440 by Dorjsuren D., et al. RMP, a novel RNA polymerase II subunit 5-interacting protein, counteracts transactivation by hepatitis B virus X protein.