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- Table of Contents

Facts about Ubiquitin carboxyl-terminal hydrolase 21.
Regulates gene expression through histone H2A deubiquitination (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no impact on Sentrin-1 conjugates (PubMed:10799498).
| Human | |
|---|---|
| Gene Name: | USP21 |
| Uniprot: | Q9UK80 |
| Entrez: | 27005 |

| Belongs to: |
|---|
| peptidase C19 family |

Deubiquitinating enzyme 21; EC 3.1.2.15; EC 3.4.19.12; MGC3394; ubiquitin carboxyl-terminal hydrolase 21; ubiquitin specific peptidase 21; ubiquitin specific protease 21; ubiquitin thioesterase 21; Ubiquitin thiolesterase 21; ubiquitin-specific processing protease 21; ubiquitin-specific protease 16; Ubiquitin-specific-processing protease 21; USP16; USP23NEDD8-specific protease
Mass (kDA):
62.656 kDA

| Human | |
|---|---|
| Location: | 1q23.3 |
| Sequence: | 1; NC_000001.11 (161159487..161165752) |
Highly expressed in heart, pancreas and skeletal muscle. Also expressed in brain, placenta, liver and kidney, and at very low level in lung.
Cytoplasm. Nucleus.






PMID: 10786635 by Smith T.S., et al. Sequencing, tissue distribution and chromosomal assignment of a novel ubiquitin-specific protease USP23.
PMID: 10799498 by Gong L., et al. Identification of a novel isopeptidase with dual specificity for ubiquitin- and NEDD8-conjugated proteins.