Ubiquitin carboxyl-terminal hydrolase 49 (USP49)

Specifically deubiquitinates histone H2B at'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing.

Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons. .