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- Table of Contents
Facts about Pantetheinase.
Human | |
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Gene Name: | VNN1 |
Uniprot: | O95497 |
Entrez: | 8876 |
Belongs to: |
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carbon-nitrogen hydrolase superfamily |
EC 3.5.1; EC 3.5.1.92; HDLCQ8; MGC116930; MGC116931; MGC116932; Pantetheinase; Pantetheine hydrolase; Tiff66; Tiff66MGC116933; vanin 1; Vanin1; Vanin-1; vannin 1; Vascular non-inflammatory molecule 1; VNN1
Mass (kDA):
57.012 kDA
Human | |
---|---|
Location: | 6q23.2 |
Sequence: | 6; NC_000006.12 (132680849..132714055, complement) |
Widely expressed with higher expression in spleen, kidney and blood. Overexpressed in lesional psoriatic skin.
Cell membrane; Lipid-anchor, GPI-anchor.
This Steven Boster bio will tell us about his family, history, and work. Then we'll explore the VNN1 marker, and its uses. After that, we'll look at some of Boster’s greatest work. We'll also take a look at how the VNN1 Marker has impacted the world. It is a marker whose sole purpose is to identify and locate targets. This is one of today's most important technologies.
As a scientist, you can find out more about the man behind the e-liquid technology that has changed laboratory research. Steve Boster was an inventor, innovator, and a pioneer. He was known as "the guy that converts science to the lavatory". He also created hundreds of primary antibodies and his company was one of the most important catalog antibody companies in China by the end of the nineties. PicoKine(tm), his own ELISA platform was developed. This patented technology enables PicoKine to provide high-sensitivity ELISA Kits.
Steve Boster, a Joliet, IL native, was born June 6, 1995. He was the child of James and Evelyn Meier, and was a long-serving manager. He was a veteran of the U.S. Army, and a Concordia Hall member in Staunton, VA. Frances of Verona in WI, his sister Tammy, his son Jonathan and many nieces/nieces are his survivors.
His research with VNN1 markers has revealed how this gene regulates PPARa activity. PPARa's main target is the VNN1 gene. It is expressed in both myofibroblasts and hepatocytes. VNN1 gene regulation is different in different models of diseased livers. His team used a mouse model with hepatitis C.
The transcription factors PPARa/PPARg tightly regulate VNN1's expression. In patients, one SNP contributes to PPARg binding site. This could help determine which patients will most benefit from 5-ASA treatment. It could also be used to detect fecal biomarkers. A VNN1 gene expression marker could be used to help determine if a medication is effective in relieving symptoms of IBD.
PMID: 9790769 by Galland F., et al. Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6.
PMID: 10567687 by Maras B., et al. Is pantetheinase the actual identity of mouse and human vanin-1 proteins?