Protein Wnt-7a (WNT7A)

Ligand for members of the frizzled family of seven transmembrane receptors which functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an essential role in embryonic development, such as dorsal versus ventral patterning during limb development, skeleton growth and urogenital tract development (PubMed:16826533).

Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:30026314). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes (By similarity).