This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
WWOX Antibodies
AND WWOX ELISA kits, WWOX Proteins
Many biological assays use antibodies to detect WWOX, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with WWOX in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop WWOX antibodies...
Previous: SEPTIN9
Next: ARID4B
WWOX Infographic by Boster Bio
All WWOX Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A01223-1
100 μg/vial
Cat # A01223-1
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M01223
100 μg/vial
Cat # M01223
100 μg/vial
Human, Mouse
ELISA
$480
Cat # EKC1600
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1600
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse
ELISA
$540
Cat # EKC2601
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2601
1 kit, containing two 96-well plates and all necessary reagents
WWOX Overview
Facts about WW domain-containing oxidoreductase.
WW domain-containing oxidoreductase (WWOX)
Putative oxidoreductase. Required for normal bone growth (By similarity).
May function synergistically with p53/TP53 to restrain genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death.
Gene Information
| Human | |
|---|---|
| Gene Name: | WWOX |
| Uniprot: | Q9NZC7 |
| Entrez: | 51741 |
Family
| Belongs to: |
|---|
| short-chain dehydrogenases/reductases (SDR) family |
Alternative Names
D16S432E; EC 1.1.1; EC 1.1.1.-; FOR; FORHHCMA56; FRA16D; Fragile site FRA16D oxidoreductase; SDR41C1; short chain dehydrogenase/reductase family 41C, member 1; WOX1; WOX1PRO0128; WW domain containing oxidoreductase; WW domain-containing oxidoreductase; WW domain-containing protein WWOX; WWOX
Molecular Weight
Mass (kDA):
46.677 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16q23.1-q23.2 |
| Sequence: | 16; NC_000016.10 (78099654..79212667) |
Tissue Specificity
Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines.
Subcellular Localizations
Cytoplasm. Nucleus. Mitochondrion. Golgi apparatus. Partially localizes to the mitochondria (PubMed:14695174). Translocates to the nucleus upon genotoxic stress or TNF stimulation (By similarity). Translocates to the nucleus in response to TGFB1 (PubMed:19366691). Isoform 5 and isoform 6 may localize in the nucleus.
Diseases
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Cell Transformation, Neoplastic
- Neoplasm Metastasis
- Carcinogenesis
- Lung Neoplasms
- Malignant Neoplasm Of Lung
- Adenocarcinoma
- Ovarian Neoplasm
Interacting Proteins
- ARRDC3
- Bcl9l
- C10orf55
- DAZAP2
- Dvl2
- Erbb4
- FAM189B
- LINC01600
- LITAF
- SHISA5
Pathways
- Methylation
- Cell Death
- Pathogenesis
- Cell Growth
- Cell Cycle
- Localization
- Cell Proliferation
- Dna Repair
- Cell Adhesion
- Reverse Transcription
- Dna Methylation
- S Phase
- Secretion
PTMs
- Phosphorylation
- Methylation
- Reduction
- Demethylation
Research Areas
- Alzheimers Research
- Apoptosis
- Cancer
- Neuroscience
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/WWOX
bosterbio.com/bosterbio-gene-info-cards/WWOX
References
PMID: 10786676 by Bednarek A.K., et al. WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer.
PMID: 10861292 by Ried K., et al. Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells.