Tyrosine-protein kinase ZAP-70 (ZAP70)

Tyrosine kinase that plays a vital role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, in addition to thymocyte development.

Contributes also into the activation and development of primary B-lymphocytes. When antigen presenting cells (APC) trigger T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 into the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif in the plasma membrane.