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- Table of Contents
Synaptotagmin-4 Antibodies
AND SYT4 ELISA kits, Synaptotagmin-4 Proteins
Many biological assays use antibodies to detect Synaptotagmin-4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Synaptotagmin-4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Synaptotagmin-4 antibodies...
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SYT4 Infographic by Boster Bio
All SYT4 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IF, IHC, WB
$523
Cat # M10762
100 µl
Cat # M10762
100 µl
Human
$628
Cat # LS006860
20 µg, 100 µg
Cat # LS006860
20 µg, 100 µg
SYT4 Overview
Facts about Synaptotagmin-4.
Synaptotagmin-4 (SYT4)
May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).
.
Gene Information
| Human | |
|---|---|
| Gene Name: | SYT4 |
| Uniprot: | Q9H2B2 |
| Entrez: | 6860 |
Family
| Belongs to: |
|---|
| synaptotagmin family |
Alternative Names
HsT1192; KIAA1342sytIV; synaptotagmin 4; synaptotagmin IVsynaptotagmin-4; SytIV
Molecular Weight
Mass (kDA):
47.958 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 18q12.3 |
| Sequence: | 18; NC_000018.10 (43267892..43277490, complement) |
Tissue Specificity
Expressed in melanocytes (PubMed:23999003). Expressed in brain. Within brain, expression is highest in hippocampus, with substantial levels also detected in amygdala and thalamus (PubMed:23999003).
Subcellular Localizations
Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane; Single-pass membrane protein.
Diseases
- Pheochromocytoma
- Pituitary Diseases
- Mental Disorders
- Anxiety Disorders
- Epilepsy
- Parkinson Disease
- Memory Disorders
- Nervousness
- Obesity
- Sensation Disorders
- Sarcoma
Interacting Proteins
- NBR1
- SGTA
Pathways
- Exocytosis
- Secretion
- Localization
- Transport
- Membrane Depolarization
- Sensitization
- Insulin Secretion
- Synaptic Transmission
- Golgi Localization
- Brain Development
- Neurotransmitter Secretion
- Reverse Transcription
- Translation
PTMs
Research Areas
- Membrane Vesicle Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SYT4
bosterbio.com/bosterbio-gene-info-cards/SYT4
References
PMID: 10938284 by Ferguson G.D., et al. The human synaptotagmin IV gene defines an evolutionary break point between syntenic mouse and human chromosome regions but retains ligand inducibility and tissue specificity.
PMID: 23999003 by Yoo J.C., et al. SYT14L, especially its C2 domain, is involved in regulating melanocyte differentiation.