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- Table of Contents
Facts about Synaptotagmin-4.
.
Human | |
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Gene Name: | SYT4 |
Uniprot: | Q9H2B2 |
Entrez: | 6860 |
Belongs to: |
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synaptotagmin family |
HsT1192; KIAA1342sytIV; synaptotagmin 4; synaptotagmin IVsynaptotagmin-4; SytIV
Mass (kDA):
47.958 kDA
Human | |
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Location: | 18q12.3 |
Sequence: | 18; NC_000018.10 (43267892..43277490, complement) |
Expressed in melanocytes (PubMed:23999003). Expressed in brain. Within brain, expression is highest in hippocampus, with substantial levels also detected in amygdala and thalamus (PubMed:23999003).
Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane; Single-pass membrane protein.
Boster bio now stocks antibodies against Synaptotagmin-4, (SYT4) The antiserum, catalog number A10762, has been tested for IHC/IF, and WB using animal models. It reacts with Human, Mouse, and Rat. In the following paragraphs, it is discussed how neuroscience can benefit from its use. Please refer to the catalog number for more information.
The anti-synaptotagmin-4 or SYT4 antibody is a highly specific polyclonal antibody that reacts well with Zebrafish. The antibody is stable at -20degC and 4degC for one-month. High affinity was achieved by the product's high concentration of 50 glycerol (0.2%) Na2HPO4 and 0.2% glycerol.
The SYT4 gene is found in the brain, but not neurons. This gene could have many applications. It is also expressed within the hippocampal region's astrocytes. Its expression has been determined using single cell RT-PCR, immunofluorescence, and immunoelectron microscopy. The marker is expressed only by astrocytes and is not present in the presynaptic postsynaptic terminals in place.
The SYT4 signal is expressed in brain and is required to form hippocampal-based mental memories. It also serves as a candidate Ca2+-sensor in gliotransmission. It is not known what role Syt IV plays in the brain. It is known that the protein plays a role in the regulation glutamate release from the astrocytes. This mechanism has implications for neural development, and may also be relevant to the formation of long-term memory.
PMID: 10938284 by Ferguson G.D., et al. The human synaptotagmin IV gene defines an evolutionary break point between syntenic mouse and human chromosome regions but retains ligand inducibility and tissue specificity.
PMID: 23999003 by Yoo J.C., et al. SYT14L, especially its C2 domain, is involved in regulating melanocyte differentiation.