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- Table of Contents
NFKBIE Antibodies
AND NFKBIE ELISA kits, NFKBIE Proteins
Many biological assays use antibodies to detect NFKBIE, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NFKBIE in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NFKBIE antibodies...
Designing an IHC experiment for NFKBIE? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the NFKBIE IHC GuideNFKBIE Infographic by Boster Bio
All NFKBIE Products
Product
Figures
Specificity
Applications
Price
Human
IP, IF, IHC, ICC, WB
$146
Cat # M07073-3
20μL, 40μL, 100μL, 200μL
Cat # M07073-3
20μL, 40μL, 100μL, 200μL
Human, Mouse, Rat
ELISA
$540
Cat # EKC1945
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC1945
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1313
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1313
1 kit, containing one 96-well plate and all necessary reagents
NFKBIE Overview
Facts about NF-kappa-B inhibitor epsilon.
NF-kappa-B inhibitor epsilon (NFKBIE)
Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes.
.
Gene Information
| Human | |
|---|---|
| Gene Name: | NFKBIE |
| Uniprot: | O00221 |
| Entrez: | 4794 |
Family
| Belongs to: |
|---|
| NF-kappa-B inhibitor family |
Alternative Names
epsilon; ikappaBepsilon; I-kappa-B-epsilon; IkB-E; IKBENF-kappa-B inhibitor epsilon; IkBepsilon; IkB-epsilon; NF-kappa-BIE; NFKBIE; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor
Molecular Weight
Mass (kDA):
52.864 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6p21.1 |
| Sequence: | 6; NC_000006.12 (44258166..44265551, complement) |
Tissue Specificity
Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages.
Subcellular Localizations
Cytoplasm.
Diseases
- Inflammation
- Malignant Neoplasms
- Neoplasms
- Rheumatoid Arthritis
- Autoimmune Diseases
- Arthritis
- Cell Transformation, Neoplastic
- Tissue Adhesions
- Autoimmune Reaction
- Immunologic Deficiency Syndromes
- Lymphoma
- Chronic Inflammation
- Diabetes Mellitus, Insulin-dependent
Interacting Proteins
- ANKHD1
- PPP6R1
- PPP6R2
- REL
Pathways
- Localization
- Pathogenesis
- Cell Activation
- Immune Response
- Cell Differentiation
- Oncogenesis
- Cell Proliferation
- Hyperphosphorylation
- Nuclear Export
- Cell Maturation
- Response To Tumor Necrosis Factor
- Translation
- Regulation Of Cytokine Production
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NFKBIE
bosterbio.com/bosterbio-gene-info-cards/NFKBIE
References
PMID: 9135156 by Whiteside S.T., et al. IkappaB epsilon, a novel member of the IkappaB family, controls RelA and cRel NF-kappaB activity.
PMID: 9315679 by Li Z., et al. A new member of the IkappaB protein family, IkappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription.