This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
ABCC3 Antibodies
AND ABCC3 ELISA kits, ABCC3 Proteins
Many biological assays use antibodies to detect ABCC3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ABCC3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ABCC3 antibodies...
Designing a Western blot for ABCC3? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ABCC3 Western Blot GuideABCC3 Infographic by Boster Bio
All ABCC3 Products
Product
Figures
Specificity
Applications
Price
ABCC3 Overview
Facts about Canalicular multispecific organic anion transporter 2.
Canalicular multispecific organic anion transporter 2 (ABCC3)
May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity).
. .
Gene Information
| Human | |
|---|---|
| Gene Name: | ABCC3 |
| Uniprot: | O15438 |
| Entrez: | 8714 |
Family
| Belongs to: |
|---|
| ABC transporter superfamily |
Alternative Names
ABC31; ATP-binding cassette sub-family C member 3; ATP-binding cassette, sub-family C (CFTR/MRP), member 3; canalicular multispecific organic anion transporter 2; canicular multispecific organic anion transporter; cMOAT2; EC 3.6.3; EC 3.6.3.44; EC 6.3.2.4; MLP2DKFZp686E22157; MRP3MOAT-DEST90757; multidrug resistance associated protein; Multidrug resistance-associated protein 3; Multi-specific organic anion transporter D
Molecular Weight
Mass (kDA):
169.343 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q21.33 |
| Sequence: | 17; NC_000017.11 (50634881..50692253) |
Tissue Specificity
Mainly expressed in the liver. Also expressed in small intestine, colon, prostate, testis, brain and at a lower level in the kidney.
Subcellular Localizations
Membrane; Multi-pass membrane protein.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Breast
- Carcinoma
- Cholestasis
- Mammary Neoplasms
- Liver Carcinoma
- Adenocarcinoma
- Malignant Paraganglionic Neoplasm
- Liver Diseases
- Malignant Neoplasm Of Lung
- Liver Neoplasms
- Lung Neoplasms
Pathways
- Transport
- Excretion
- Localization
- Drug Resistance
- Drug Transport
- Secretion
- Intestinal Absorption
- Cell Differentiation
- Conjugation
- Cellular Localization
- Gene Silencing
- Immune Response
- Organic Anion Transport
PTMs
- Phosphorylation
- Carboxylation
- Reduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ABCC3
bosterbio.com/bosterbio-gene-info-cards/ABCC3
References
PMID: 9813153 by Uchiumi T., et al. Isolation of a novel human canalicular multispecific organic anion transporter, cMOAT2/MRP3, and its expression in cisplatin-resistant cancer cells with decreased ATP-dependent drug transport.
PMID: 9738950 by Kiuchi Y., et al. cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3).